| SOA-48 | University of Pretoria | Pretoria | SOUTH AFRICA | AFRO | WHO Collaborating Centre for Prevention of Deafness and Hearing Loss | CHADHA Shelly | Active | Details |
| SOA-49 | University of the Free State | Bloemfontein | SOUTH AFRICA | AFRO | WHO Collaborating Centre for Vaccine Preventable Diseases Surveillance and Pathogens Genomics | MATHIU Jason Mwenda | Active | Details |
| SOA-47 | University of Cape Town | Cape Town | SOUTH AFRICA | AFRO | WHO Collaborating Centre for Trachoma | SOLOMON Anthony | Active | Details |
| SOA-39 | Stellenbosch University | TYGERBERG | SOUTH AFRICA | AFRO | WHO Collaborating Center for Bioethics | REIS Andreas Alois | Active | Details |
| SOA-38 | University of KwaZulu-Natal | Durban | SOUTH AFRICA | AFRO | WHO Collaborating Centre for Pharmaceutical Policy and Evidence Based Practice | IYENGAR Swathi Bhargav | Active | Details |
| SOA-34 | University of Cape Town | Cape town | SOUTH AFRICA | AFRO | WHO Collaborating Centre for Mental Health and Psychiatry | GRAY Brandon | Active | Details |
| SOA-27 | National Institute for Occupational Health (NIOH) | Johannesburg | SOUTH AFRICA | AFRO | WHO Collaborating Centre for Occupational Health | PEGA Frank | Active | Details |
| SOA-43 | National Institute for Communicable Diseases | Johannesburg | SOUTH AFRICA | AFRO | WHO Collaborating Centre for Antimicrobial Resistance | COULIBALY Sheick Oumar | Active | Details |
| SOA-14 | University of South Africa (UNISA) | Pretoria | SOUTH AFRICA | AFRO | WHO Collaborating Centre for Postgraduate Distance Education and Research in Nursing and Midwifery Development | ASAMANI James Avoka | Active | Details |
| SOA-18 | University of Western Cape | Cape Town | SOUTH AFRICA | AFRO | WHO Collaborating Centre for Research and Training in Human Resource for Health Development | AHMAT Adam | Active | Details |
| SOA-13 | University of Natal | Durban | SOUTH AFRICA | AFRO | WHO Collaborating Centre for Educating Nurses and Midwives in Community Problem-solving | ASAMANI James Avoka | Active | Details |
| SOA-50 | Sefako Makgatho Health Sciences University | Pretoria | SOUTH AFRICA | AFRO | WHO Collaborating Centre for Diarrhoeal Diseases Research and surveillance | MATHIU Jason Mwenda | Active | Details |
| SOA-5 | University of Western Cape | Cape Town | SOUTH AFRICA | AFRO | WHO Collaborating Centre for Oral Health | MAKINO Yuka | Active | Details |