Efficacy and Safety of Pirfenidone in Patient With Systemic Sclerosis-associated Interstitial Lung Disease

• Register: ClinicalTrials.gov
• Last refreshed on: 12 December 2020
• Main ID: NCT03856853
• Date of registration: 26/02/2019
• Prospective Registration: No
• Primary sponsor: Beijing Continent Pharmaceutical Co, Ltd.
• Public title: Efficacy and Safety of Pirfenidone in Patient With Systemic Sclerosis-associated Interstitial Lung Disease
• Scientific title: A Phase III, Randomized, Double-blind, Placebo Controlled, Multicenter Clinical Trial to Evaluate the Efficacy and Safety of Pirfenidone in Subjects With Systemic Sclerosis-associated Interstitial Lung Disease (SSc-ILD)
• Date of first enrolment: June 15, 2018
• Target sample size: 144
• Recruitment status: Recruiting
• URL: https://clinicaltrials.gov/show/NCT03856853
• Study type: Interventional
• Study design: Allocation: Randomized. Intervention model: Parallel Assignment. Primary purpose: Treatment. Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor).
• Phase: Phase 3

Countries of recruitment

China

Contacts

• Name: Ling Zhang

Key inclusion & exclusion criteria

Inclusion Criteria:

1.Female or male subjects aged between 18 and 75 years of age. 2.2013 ACR / EULAR
classification criteria for SSc fulfilled. 3.SSc disease onset (defined by first
non-Raynaud symptom) within 5 years. 4.SSc related Interstitial Lung Disease confirmed by
HRCT. 5.Forced vital capacity (FVC) 40% to 70% predicted(include 40% and70% ). 6.Subject
have the ability to understand and sign the informed consent before the trials.

Exclusion Criteria:

1. Subjects not fulfill all of the above inclusion criteria.

2. AST, ALT >1.5 x ULN.

3. Bilirubin >1.5 x ULN.

4. Creatinine clearance <30 mL/min.

5. Airway obstruction (pre-bronchodilator FEV1/FVC <0.7).

6. Other clinically significant pulmonary abnormalities.

7. Allergic to test drugs or components (e.g. lactose).

8. Clinical Significant Pulmonary hypertension:.

1. Significant past clinical evidence or echocardiography of right heart failure.

2. History of right heart catheterization showed that cardiac index = 2 l/min/m2.

3. Pulmonary hypertension, which needs to use EPoprostenol/ Treprostinil for
parenteral treatment .

9. Cardiovascular diseases:

1. Six weeks in severe hypertension, and out of control after
treatment(=160/100mmHg).

2. Myocardial infarction within six months.

3. A period of 6 months in unstable angina.

10. More than 3 digital fingertip ulcers or a history of severe digital necrosis requiring
hospitalization or severe other ulcers.

11. Bleeding risk, including the following criterias:

a. Predisposition to bleeding. b.Subjects need to the following treatments:
i.Fibrinolysis, full-dose anticoagulation therapy(such as vitamin K antagonists,
direct thrombin inhibitor, heparin, Hirudin ).

ii. High dose antiplatelet therapy[Note: not prohibited to maintain equipment needed
indwelling venous pathway prophylactic low dose of heparin or heparin fluid (e.g.
enoxaparin, daily 4000 I.U. s.c.) and the prevention of the use of antiplatelet
therapy (e.g. acetylsalicylic acid, until 325 mg/d, or other antiplatelet dose of 75
mg/d the same dose of clopidogrel, or treatment)].

c.history of hemorrhagic central nervous system (CNS) event within last year. d. Any
of the following conditions within 3 months: i.Hemoptysis or hematuria ii. Active
gastrointestinal bleeding or gastrointestinal ulcer. iii. major trauma or major
surgery (researchers determined). e.coagulation parameters:international normalised
ratio (INR) >2, prolongation of prothrombin time (PT) and partial thromboplastin time
(PTT) by >1.5 x ULN)

12. May interfere with detection procedures (such as interrupt oxygen intolerance in
pulmonary function tests) or based on the researchers estimate, may affect the test to
participate in or participate in the test may put patients at risk of disease or other
complications (such as caused by SSc severe gastrointestinal symptoms).

13. Researchers determined that life expectancy was due to other diseases (non SSc) for a
period of up to 2.5 years.

14. Clinical signs of malabsorption or needing parenteral nutrition.

15. History of thrombotic event within last year(Including stroke and transient ischemic
attack).

16. Previous treatment with nintedanib or pirfenidone.

17. Use the following medicine:

1. Treatment with prednisone >10 mg/day within 2 weeks.

2. Treatment with azathioprine, hydroxychloroquine, colchizine, D-penicillamine,
sulfasalazine within 8 weeks .

3. Treatment with cyclophosphamide, rituximab, tocilizumab, abatacept, leflunomide,
tacrolimus, newer anti-arthritic treatments like tofacitinib and ciclosporine A,
potassium para-aminobenzoate within 6 months.

18. Unstable background therapy with cyclophosphamide or mycophenolate mofetil / sodium or
methotrexate (not allow treatment). Patients must or A. patients cannot receive
immunosuppressive therapy, sodium cyclophosphamide or mycophenolate mofetil / or MTX
stable or B. within 6 months of acceptance, and in at least 6 months after
randomization, the treatment to keep the background stable (exclusion criteria 16 and
17 and the combined use of early precautions).

19. Previous or planned hematopoietic stem cell transplantation next year.

20. Major surgery is planned during the treatment period.

21. Pregnancy or lactation or make a schedule during the trials.

22. Give the drug 28 days before or after administration of the 3 month period, women of
childbearing age * are unwilling or unable to use contraceptive methods highly
effective (according to ICH M3 (R2)), a highly effective means in the correct and
consistent application of a barrier method when the failure rate of less than 1% per
year. * women of childbearing age is defined has undergone menarche and in line with
"infertile women" standard "[female infertile women" is defined as: postmenopausal
period (12 months without menstruation, no other medical reasons) or permanent
sterilization (e.g., tubal occlusion, hysterectomy, bilateral ovarian resection or
bilateral tubal resection women)].

(23)According to the researchers,exhibited evidence of alcohol or drug abuse. (24)Patients
who were unable to understand or comply with the procedure were included in the
self-administered questionnaire, which was completed without help.

25.Patients with underlying chronic liver disease (Child Pugh A, B, C hepatic impairment).

26.Clinical signs of malabsorption or needing parenteral nutrition. 27.With active peptic
ulcer. 28.With mental illness . 29.Within 3 months to participate in other clinical trials.
30.Researchers determined that they did not participate in the trial.



Age minimum: 18 Years
Age maximum: 75 Years
Gender: All

Health Condition(s) or Problem(s) studied

Systemic Sclerosis-associated Interstitial Lung Disease (Ssc-ild)

Intervention(s)

Other: placebo

Drug: Pirfenidone

Primary Outcome(s)

Relative change from baseline (%) of FVC% [Time Frame: 52 Weeks]

Secondary ID(s)

GNI-F647-1701

Source(s) of Monetary Support

Please refer to primary and secondary sponsors

Secondary Sponsor(s)

GNI-EPS Pharmaceuticals, Inc. (GNI Group)

Shanghai Genomics, Inc.