Intervention(s)
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Diagnostic Test: initial fecal microbiome
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Diagnostic Test: VOC probiotic
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Diagnostic Test: Functional residual capacity
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Dietary Supplement: Probiotic treatment
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Diagnostic Test: Maximum oxygen uptake
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Diagnostic Test: Fecal microbiome probiotic
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Diagnostic Test: initial pulmonary microbiome
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Diagnostic Test: initial VOC
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Diagnostic Test: Pulmonary microbiome probiotic
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Primary Outcome(s)
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Analysis of the cardiopulmonary capacity: Body fat of CDH group versus control group.
[Time Frame: 12 months]
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Analysis of the cardiopulmonary capacity: Oxygen uptake of CDH group versus control group.
[Time Frame: 12 months]
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Analysis of the lung function: Forced expiratory volume in one second (FEV1) measured with spirometry of CDH group versus control group.
[Time Frame: 12 months]
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Analysis of VOCs in the respiratory air by needle-trap microextraction (NTME) and stool by solid phase microextraction (SPME) of CDH group versus control group.
[Time Frame: 12 months]
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Analysis of the cardiopulmonary capacity: Body mass index (BMI) of CDH group versus control group.
[Time Frame: 12 months]
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Analysis of the cardiopulmonary capacity: Muscle mass of CDH group versus control group.
[Time Frame: 12 months]
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Analysis of the cardiopulmonary capacity: Aerobic performance of CDH group versus control group.
[Time Frame: 12 months]
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Analysis of the cardiopulmonary capacity: Breathing reserve of CDH group versus control group.
[Time Frame: 12 months]
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Analysis of the cardiopulmonary capacity: Body height of CDH group versus control group.
[Time Frame: 12 months]
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Analysis of the cardiopulmonary capacity: Ventilation of CDH group versus control group.
[Time Frame: 12 months]
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Analysis of the cardiopulmonary capacity: Body weight of CDH group versus control group.
[Time Frame: 12 months]
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Analysis of the cardiopulmonary capacity: Oxygen pulse of CDH group versus control group.
[Time Frame: 12 months]
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Analysis of the cardiopulmonary capacity: Systolic and diastolic blood pressures of CDH group versus control group.
[Time Frame: 12 months]
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Analysis of the pulmonary microbiome in the sputum of CDH group versus control group.
[Time Frame: 12 months]
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Analysis of the cardiopulmonary capacity: Maximal oxygen uptake of CDH group versus control group.
[Time Frame: 12 months]
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Analysis of the cardiopulmonary capacity: Resting ECG of CDH group versus control group.
[Time Frame: 12 months]
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Analysis of the lung function: Lung clearance index (LCI) is derived from multiple breath washout tests of CDH group versus control group.
[Time Frame: 12 months]
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Secondary Outcome(s)
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Analysis of the lung function: Forced expiratory volume (FEV1).
[Time Frame: 12 months]
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Alterations of pulmonary microbiome after probiotic treatment for a period of 3 months in patients with CDH.
[Time Frame: 12 months]
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Analysis of the lung function: Max. expiratory flow (MMEF).
[Time Frame: 12 months]
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Analysis of the lung function: Through "multiple breath washout" acquired FRC (RC(MBW)).
[Time Frame: 12 months]
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Analysis of the lung function: Forced expiratory flow (FEF25).
[Time Frame: 12 months]
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Analysis of the lung function: Forced expiratory flow (FEF50).
[Time Frame: 12 months]
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Analysis of the lung function: Intrathoracic gasvolume (ITGV).
[Time Frame: 12 months]
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Alterations of VOCs in the respiratory air after probiotic treatment for a period of 3 months in patients with CDH.
[Time Frame: 12 months]
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Analysis of the lung function: Forced vital capacity (FVC).
[Time Frame: 12 months]
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Analysis of the lung function: Max. expiratory flow (MEF50).
[Time Frame: 12 months]
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Analysis of the lung function: Forced expiratory flow (FEF25-75).
[Time Frame: 12 months]
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Analysis of the lung function: Functional residual capacity (FRC).
[Time Frame: 12 months]
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Analysis of the lung function: Max. expiratory flow (MEF25).
[Time Frame: 12 months]
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Analysis of the lung function: Through body plethysmography acquired FRC (RC(pleth)).
[Time Frame: 12 months]
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Analysis of the lung function: Tiffeneau-Index (FEV1%FVC).
[Time Frame: 12 months]
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