Primary Outcome(s)
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CFB in Activated Partial Thromboplastin Time - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Aggregate QRS Duration - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Eosinophils to Leukocytes Ratio (%) - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Lipase - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Lymphocytes to Leukocytes Ratio (%) - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Standing Diastolic Blood Pressure - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part II/III Score - Part B
[Time Frame: Baseline, Days 1 to 6 (12 and 23 hours postdose), Day 7 (12 hours postdose), Day 14]
|
Percentage of Participants With a Response of 'Yes' to Any Columbia Suicide Severity Rating Scale (C-SSRS) Suicidal Ideation or Suicidal Behavior Item - Part A
[Time Frame: Day 1 to Day 14]
|
Percentage of Participants With Treatment-emergent Adverse Events (TEAEs) - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Bilirubin - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Creatinine - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Heart Rate - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Phosphate - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Potassium - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Sodium - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Standing Systolic Blood Pressure - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Stanford Sleepiness Scale (SSS) Score - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Aggregate PR Interval - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Aggregate QT Interval - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Monocytes - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Protein - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Aspartate Aminotransferase - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Basophils to Leukocytes Ratio [Percentage (%)] - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Electrocardiogram (ECG) Mean Heart Rate - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Hematocrit - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Platelets - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Prothrombin International Normalized Ratio - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Supine Diastolic Blood Pressure - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Calcium - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Erythrocytes - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in pH - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Aggregate QTcF Interval - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Alanine Aminotransferase - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Alkaline Phosphatase - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Eosinophils - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Leukocytes - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Magnesium - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Respiratory Rate - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Temperature - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Urate - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Urea Nitrogen - Part A
[Time Frame: Day 1 to Day 14]
|
Change From Baseline (CFB) in Basophils - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Aggregate RR Interval - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Albumin - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Monocytes to Leukocytes Ratio (%) - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Neutrophils- Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Reticulocytes - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Specific Gravity - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Pulse Oximetry- Part A
[Time Frame: Day 1 to Day 14]
|
Percentage of Participants With TEAEs, Graded by Severity - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Bicarbonate - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Chloride - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Hemoglobin - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Lymphocytes - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Neutrophils to Leukocytes Ratio (%) - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Prothrombin Time - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Reticulocytes to Erythrocytes Ratio (%) - Part A
[Time Frame: Day 1 to Day 14]
|
CFB in Supine Systolic Blood Pressure - Part A
[Time Frame: Day 1 to Day 14]
|
Secondary Outcome(s)
|
CFB in Aggregate RR Interval - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Bilirubin - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Monocytes to Leukocytes Ratio (%) - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Reticulocytes - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Urea Nitrogen - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Alanine Aminotransferase - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Aspartate Aminotransferase - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in ECG Mean Heart Rate - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Eosinophils to Leukocytes Ratio (%) - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Specific Gravity - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Supine Diastolic Blood Pressure - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Aggregate PR Interval - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Aggregate QRS Duration - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Eosinophils - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Leukocytes - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Monocytes - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Phosphate - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Potassium - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Standing Diastolic Blood Pressure - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Supine Systolic Blood Pressure - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in the MDS-UPDRS Part II Total Score - Part B
[Time Frame: Baseline, Days 1 to 6 (12 and 23 hours postdose), Day 7 (12 hours postdose), Day 14]
|
CFB in Bicarbonate - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Neutrophils - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Creatinine - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Heart Rate - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Aggregate QTcF Interval - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Alkaline Phosphatase - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Albumin - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Chloride - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Activated Partial Thromboplastin Time - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Aggregate QT Interval - Part B
[Time Frame: Day 1 to Day 14]
|
Percentage of Participants With TEAEs - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Lymphocytes to Leukocytes Ratio (%) - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Neutrophils to Leukocytes Ratio (%) - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Platelets - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Standing Systolic Blood Pressure - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Temperature - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in the MDS-UPDRS Part I Total Score - Part B
[Time Frame: Baseline, Day 7 (12 hours postdose), Day 14]
|
CFB in the MDS-UPDRS Part III Total Score - Part B
[Time Frame: Baseline, Days 1 to 6 (12 and 23 hours postdose), Day 7 (12 hours postdose), Day 14]
|
MDS-UPDRS Part III Total Score - Part A
[Time Frame: Days 1 to 7 (2, 4, 8, and 12 hours postdose), Day 8 and Day 14]
|
Percentage of Participants With a Response of 'Yes' to Any C-SSRS Suicidal Ideation or Suicidal Behavior Item - Part B
[Time Frame: Day 1 to Day 14]
|
Percentage of Participants With TEAEs, Graded by Severity - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Hematocrit - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Lipase - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in pH - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Protein - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Prothrombin Time - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Urate - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Basophils to Leukocytes Ratio (%) - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Hemoglobin - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Magnesium - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Prothrombin International Normalized Ratio - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Pulse Oximetry - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Respiratory Rate - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Basophils - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Calcium - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Reticulocytes to Erythrocytes Ratio (%) - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Sodium - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Erythrocytes - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in Lymphocytes - Part B
[Time Frame: Day 1 to Day 14]
|
CFB in the MDS-UPDRS Part I-IV Total Score - Part B
[Time Frame: Baseline, Day 7 (12 hours postdose), Day 14]
|