Clinical Study Evaluating the Effects of First-line Oral cOmbination theraPy of maciTentan and tadalafIl in Patients With Newly Diagnosed pulMonary Arterial Hypertension (OPTIMA)

• Register: ClinicalTrials.gov
• Last refreshed on: 12 December 2020
• Main ID: NCT02968901
• Date of registration: 14/11/2016
• Prospective Registration: No
• Primary sponsor: Actelion
• Public title: Clinical Study Evaluating the Effects of First-line Oral cOmbination theraPy of maciTentan and tadalafIl in Patients With Newly Diagnosed pulMonary Arterial Hypertension (OPTIMA) OPTIMA
• Scientific title: Prospective, Multicenter, Open-label Study Evaluating the Effects of First-line Oral Combination Therapy of Macitentan and Tadalafil in Patients With Newly Diagnosed Pulmonary Arterial Hypertension (OPTIMA).
• Date of first enrolment: September 1, 2015
• Target sample size: 46
• Recruitment status: Terminated
• URL: https://clinicaltrials.gov/show/NCT02968901
• Study type: Interventional
• Study design: Allocation: N/A. Intervention model: Single Group Assignment. Primary purpose: Treatment. Masking: None (Open Label).
• Phase: Phase 4

Countries of recruitment

France

Key inclusion & exclusion criteria

Inclusion Criteria :

1. Signed informed consent prior to any study-mandated procedure.

2. Male or female = 18 and = 75 years of age at screening.

3. Initial PAH diagnosis < 6 months prior to Day 1.

4. Right heart catheterization (RHC) performed between Day -28 and Day 1 (RHC data
obtained at the study site within this time frame, but before the study, i.e., before
signed informed consent, are acceptable), meeting all the following criteria:

- Resting mean pulmonary arterial pressure (mPAP) = 25 mmHg.

- Pulmonary capillary wedge pressure (PCWP) or left ventricular end diastolic
pressure (LVEDP) = 15 mmHg.

- PVR = 400 dyn·sec/cm5 (= 5 Wood units) if PCWP < 12 mmHg OR PVR = 500 dyn·sec/cm5
(= 6.25 Wood units) if PCWP in [12-15] mmHg.

- Negative vasoreactivity test mandatory in idiopathic PAH (at this or a previous
RHC).

5. World Health Organization (WHO) Functional Class (FC) II to III.

6. PAH etiology belonging to one of the following groups:

- Idiopathic.

- Heritable.

- Anorexigens induced.

- Associated with one of the following:

- Connective tissue disease

- Congenital heart disease with simple systemic-to-pulmonary shunt (atrial
septal defect, ventricular septal defect, patent ductus arteriosus) =1 year
after surgical repair

- HIV infection

7. 6MWD = 50 m at screening.

8. Woman of childbearing potential [see definition in Section 4.5.1] must:

- Have a negative serum pregnancy test at the screening visit and a negative urine
pregnancy test at the D1 visit, and

- Agree to perform monthly pregnancy tests up to 30 days after EOT2, and

- Agree to use reliable contraception [defined in Section 4.5.2] from screening up
to 30 days after EOT2. Reliable contraception must be started at least 11 days
prior to Day 1.

Exclusion Criteria:

1. Any PAH-specific drug therapy [e.g. any endothelin receptor antagonist,
phosphodiesterase-5 inhibitors (PDE-5i), soluble guanylate cyclase stimulator,
prostacyclin, prostacyclin analog, or prostacyclin receptor agonist] at any time prior
to Day 1 (single-dose administration for vasoreactivity testing is permitted; previous
iloprost used intermittently for the treatment of digital ulcers or Raynaud's
phenomenon is permitted if stopped > 6 months prior to Day 1).

2. Subjects who changed the dose or discontinued calcium channel blockers within 1 week
prior to Day 1.

3. Initiation of diuretics within 1 week prior to RCH.

4. Subjects on oral diuretics in whom the dose has not been stable for at least 1 week
prior to RHC.

5. Treatment with other PDE-5i for erectile dysfunction.

6. Treatment with strong inducers of CYP3A4 (e.g., carbamazepine, rifampin, rifampicin,
rifabutin, rifapentin, phenobarbital, phenytoin, and St. John's wort) = 28 days prior
to Day 1.

7. Treatment with strong inhibitors of CYP3A4 (e.g., ketoconazole, itraconazole,
voriconazole, clarithromycin, telithromycin, nefazodone, ritonavir, boceprevir,
telaprevir, saquinavir, lopinavir, fosamprenavir, darunavir, tipranavir, atazanavir,
nelfinavir, amprenavir, indinavir) = 28 days prior to Day 1.

8. History of priapism.

9. Significant aortic and mitral valve disease requiring a specific treatment.

10. Pericardial constriction.

11. Life-threatening arrhythmia.

12. Uncontrolled hypertension.

13. Symptomatic coronary artery disease.

14. Cardio-pulmonary rehabilitation program based on exercise (planned, or started = 12
weeks prior to Day 1).

15. Body mass index (BMI) > 40 kg/m2 at screening.

16. Acute myocardial infarction = 12 weeks prior to Day 1.

17. Known permanent atrial fibrillation.

18. Low blood pressure < 90/50 mmHg at screening or Day 1.

19. Ongoing or planned treatment with nitrates and/or doxazosin.

20. DLCO < 40% of predicted value (eligible only if no sign of veno-occlusive disease
according to adjudication committee);

21. Presence of = 1 of the following signs of relevant lung disease at any time prior to
Day 1:

- FEV1/FVC < 70% and FEV1 < 65% of predicted after bronchodilator administration;

- Total Lung Capacity (TLC) < 60% of predicted.

22. Known or suspicion of pulmonary veno-occlusive disease (PVOD).

23. Severe renal insufficiency (estimated creatinine clearance = 30 mL/min/1.73m²)
assessed by central laboratory at screening.

24. Ongoing or planned dialysis.

25. Documented severe hepatic impairment (with or without cirrhosis) according to National
Cancer Institute organ dysfunction working group criteria, defined as total bilirubin
> 3 x ULN accompanied by AST > ULN (assessed by central laboratory at screening)
and/or Child-Pugh Class C.

26. Serum AST and/or ALT > 3 x ULN (assessed by central laboratory at screening).

27. Porto-pulmonary hypertension.

28. Hemoglobin < 100 g/L assessed by central laboratory at screening.

29. Hypersensitivity to any active substance or excipient of macitentan or tadalafil
formulation.

30. Loss of vision in one eye because of non-arteritic anterior ischemic optic neuropathy
(NAION), regardless of whether or not this episode was in connection with previous
PDE-5i exposure.

31. Hereditary degenerative retinal disorders, including retinitis pigmentosa.

32. Pregnancy, breast-feeding, intention to become pregnant during the study or woman of
childbearing potential not agree to use reliable method of contraception from
screening up to 30 days after EOT2.

33. Hereditary problems of galactose intolerance, Lapp lactase deficiency,
glucosegalactose malabsorption.

34. Any factor or condition likely to affect protocol compliance of the patient as judged
by the investigator.

35. Treatment with another investigational drug (planned, or taken = 12 weeks prior to Day
1).

36. Concomitant life-threatening disease with a life expectancy < 12 months.



Age minimum: 18 Years
Age maximum: 75 Years
Gender: All

Health Condition(s) or Problem(s) studied

Pulmonary Arterial Hypertension

Intervention(s)

Drug: macitentan

Drug: tadalafil

Primary Outcome(s)

pulmonary vascular resistance (PVR) [Time Frame: 16 weeks]

Secondary Outcome(s)

cardiac index (CI) [Time Frame: Week 16]

6MWD [Time Frame: Week 16]

mean pulmonary arterial pressure (mPAP) [Time Frame: Week 16]

mean right atrial pressure (mRAP) [Time Frame: Week 16]

WHO functional class [Time Frame: Week 16]

total pulmonary resistance (TPR) [Time Frame: Week 16]

level NT-proBNP [Time Frame: Week 16]

mixed venous oxygen saturation (Sv02) [Time Frame: Week 16]

Number of treatment goals [Time Frame: Week 16]

Secondary ID(s)

AC-055-405

Source(s) of Monetary Support

Please refer to primary and secondary sponsors