Effect of Water Intake and Water Restriction on Total Kidney Volume in Autosomal Dominant Polycystic Kidney Disease

• Register: ClinicalTrials.gov
• Last refreshed on: 16 December 2017
• Main ID: NCT02776241
• Date of registration: 04/05/2016
• Prospective Registration: No
• Primary sponsor: Rigshospitalet, Denmark
• Public title: Effect of Water Intake and Water Restriction on Total Kidney Volume in Autosomal Dominant Polycystic Kidney Disease
• Scientific title: Effect of Water Intake and Water Restriction on Total Kidney Volume in Autosomal Dominant Polycystic Kidney: The HYDRA Study
• Date of first enrolment: September 2015
• Target sample size: 40
• Recruitment status: Completed
• URL: https://clinicaltrials.gov/show/NCT02776241
• Study type: Interventional
• Study design: Allocation: Randomized. Intervention model: Parallel Assignment. Primary purpose: Diagnostic. Masking: None (Open Label).
• Phase: N/A

Countries of recruitment

Denmark

Contacts

• Name: Signe V Naver, MD
• Affiliation: Rigshospitalet, Denmark

Key inclusion & exclusion criteria

Inclusion Criteria:

- ADPKD

- CKD stage 1-3

Exclusion Criteria:

- Patients treated with diuretics

- Pregnancy

- Change in antihypertensive treatment < 1 month

- Any condition contraindicating MR scan



Age minimum: 18 Years
Age maximum: N/A
Gender: All

Health Condition(s) or Problem(s) studied

ADPKD

Intervention(s)

Other: water

Primary Outcome(s)

Change in total kidney volume [Time Frame: Baseline and 3 hours]

Secondary Outcome(s)

Change in total cyst volume [Time Frame: Baseline and 3 hours]

Change in plasma aldosterone [Time Frame: Baseline and 3 hours]

Change in plasma copeptin [Time Frame: Baseline and 3 hours]

Change in plasma renin [Time Frame: Baseline and 3 hours]

Secondary ID(s)

HYDRA

Source(s) of Monetary Support

Please refer to primary and secondary sponsors

Secondary Sponsor(s)

Aarhus University Hospital