Effect of Broccoli Sprout Extract on Keratinocyte Differentiation in Normal Skin

• Register: ClinicalTrials.gov
• Last refreshed on: 16 December 2017
• Main ID: NCT02592954
• Date of registration: 29/10/2015
• Prospective Registration: No
• Primary sponsor: Johns Hopkins University
• Public title: Effect of Broccoli Sprout Extract on Keratinocyte Differentiation in Normal Skin
• Scientific title: Effect of Broccoli Sprout Extract on Keratinocyte Differentiation in Normal Skin
• Date of first enrolment: September 2015
• Target sample size: 5
• Recruitment status: Completed
• URL: https://clinicaltrials.gov/show/NCT02592954
• Study type: Interventional
• Study design: Allocation: Non-Randomized. Intervention model: Single Group Assignment. Primary purpose: Other. Masking: Single (Participant).
• Phase: Phase 1

Countries of recruitment

United States

Contacts

• Name: Bernard Cohen, MD
• Affiliation: Professor of Dermatology

Key inclusion & exclusion criteria

Inclusion Criteria:

- Able to attend 3 visits at the designated times.

Exclusion Criteria:

- Pregnant

- Known allergy to broccoli, lidocaine, or epinephrine



Age minimum: 18 Years
Age maximum: N/A
Gender: All

Health Condition(s) or Problem(s) studied

Pachyonychia Congenita

Epidermolysis Bullosa Simplex

Intervention(s)

Drug: Jojoba oil (placebo)

Drug: Jojoba oil with broccoli sprout extract

Primary Outcome(s)

Immunohistochemistry [Time Frame: Within 1 month of skin biopsy]

Real time- Polymerase Chain Reaction [Time Frame: Within 1 month of skin biopsy]

Secondary Outcome(s)

Adverse Events [Time Frame: During the trial until 2 months after the trial ends]

Secondary ID(s)

BSE2015

Source(s) of Monetary Support

Please refer to primary and secondary sponsors