Esophageal Absorption in EoE

• Register: ClinicalTrials.gov
• Last refreshed on: 8 August 2016
• Main ID: NCT02314455
• Date of registration: 10/11/2014
• Prospective Registration: No
• Primary sponsor: Mayo Clinic
• Public title: Esophageal Absorption in EoE EoE
• Scientific title: Esophageal Absorption in Eosinophilic Esophagitis
• Date of first enrolment: September 2014
• Target sample size: 14
• Recruitment status: Terminated
• URL: https://clinicaltrials.gov/show/NCT02314455
• Study type: Interventional
• Study design: Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
• Phase: N/A

Countries of recruitment

United States

Contacts

• Name: David Katzka, MD
• Affiliation: Mayo Clinic

Key inclusion & exclusion criteria

Inclusion Criteria:

- Patients between the ages of 18 and 80 with eosinophilic esophagitis diagnosed by a
combination of compatible symptoms, endoscopic findings, histology, and lack of
response to proton pump inhibitors or negative pH study

- endoscopy with esophageal and duodenal biopsies within two weeks of performance of
this study

- Patients between the ages of 18 and 80 with eosinophilic esophagitis diagnosed by a
combination of compatible symptoms, endoscopic findings, histology, and lack of
response to proton pump inhibitors or negative pH study, and are now in histologic
remission( <15phf) by the use of steroids or the six food elimination diet.

- Volunteers will be selected for not having any history of esophageal symptoms

Exclusion Criteria:

- Vulnerable populations, such as those with diminished mental acuity, will be
excluded.

- Patients taking Nsaids within 48 hours of the d-xylose testing

- artificial sweeteners within 48 hours of the d-xylose testing

- History of IBD

- Currently smoking or history of smoking

- History of Celiac disease

- Bacterial overgrowth,

- motility disorders

- other diffuse small bowel diseases.



Age minimum: 18 Years
Age maximum: 80 Years
Gender: Both

Health Condition(s) or Problem(s) studied

Eosinophilic Esophagitis

Intervention(s)

Other: D-xylose

Primary Outcome(s)

Reliability of the d-xylose testing defined by the serum levels [Time Frame: 1 year]

Secondary Outcome(s)

D-xylose testing compared to endoscopy/biopsy findings. [Time Frame: 1 year]

Secondary ID(s)

13-009092

Source(s) of Monetary Support

Please refer to primary and secondary sponsors