Main
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Note: This record shows only 22 elements of the WHO Trial Registration Data Set. To view changes that have been made to the source record, or for additional information about this trial, click on the URL below to go to the source record in the primary register. |
Register:
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ClinicalTrials.gov |
Last refreshed on:
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19 February 2015 |
Main ID: |
NCT00901849 |
Date of registration:
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13/05/2009 |
Prospective Registration:
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No |
Primary sponsor: |
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Public title:
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Tarceva/Rapamycin for Children With Low-grade Gliomas With or Without Neurofibromatosis Type 1 (NF1)
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Scientific title:
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Phase 1 Study of Tarceva and Rapamycin For Recurrent Low-Grad Gliomas in Children With or Without Neurofibromatosis Type 1 (NF1) |
Date of first enrolment:
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May 2007 |
Target sample size:
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21 |
Recruitment status: |
Completed |
URL:
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http://clinicaltrials.gov/show/NCT00901849 |
Study type:
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Interventional |
Study design:
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Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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Phase:
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Phase 1
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Countries of recruitment
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United States
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Key inclusion & exclusion criteria
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Inclusion Criteria:
- children less than 21 years of age, with or without neurofibromatosis, with recurrent
low-grade gliomas.
- patients with or without NF1 must have failed some form of conventional therapy,
radiotherapy, or chemotherapy (carboplatin/vincristine) to be eligible, including
those treated wtih initial surgery. Patients do not have to have received
radiotherapy to be eligible.
- children with all types of histologically proven low-grade gliomas will be eligible;
re-operation at the time of recurrence is not mandatory for entry on study.
- patients with intrinsic brain lesions, believed neuroradiographically consistent with
a low-grade glial tumor, with neurofibromatosis type 1 can be treated without
histological confirmation.
- patients without neurofibromatosis type 1 must have histological confirmation of a
low-grade glial tumor prior to entry on study.
- patients must have a Karnofsky score of greater than or equal to 50% for children
greater than 10 years of age, or a Lansky score of greater than or equal to 50% for
patients less than 10 years of age.
- patients who are unable to walk because of paralysis, but who are able to use a
wheelchair, will be considered ambulatory for purposes of assessing performance
score.
- patients must have a life expectancy of at least 12 weeks.
- patients must be able to swallow medication in tablet form.
- patients must have adequate organ function, including: peripheral ANC of greater than
1,000/microliters; a platelet count of greater than 100,000/microliters; hemoglobin
of greater than 8 gms,dl (pRBC transfusions of allowed to maintain hemoglobin > 8
g/dl)
- patients must have adequate renal function, which is defined as a normal serum
creatinine for age
- patients must have adequate liver function, as defined as a total bilirubin or less
than 1.5 times the upper limit of normal for age, and an SGPT (ALT) of less than 2.5
times the upper limit of normal for age
- patients must have had a MR scan within 3 weeks of starting treatment
- all patients, and/or their parents or legal guardian, must sign a recent informed
consent
- all institutional, FDA, and NCI requirements for human study must be met.
Exclusion Criteria:
- patients must not have any other active tumors.
- pregnancy or breast feeding is an exclusion criteria, as the potential mutagenicity
and cytotoxicity of these drugs in developing fetuses are unknown. A pregnancy test
must be obtained in females who are postmenarchal. Males or females of reproductive
potential may not participate unless they have agreed to use an effective
contraceptive method.
- patients with uncontrolled infection are excluded.
- patients who have previously received Tarceva or Rapamycin are excluded.
- patients on antiepileptics and/or corticosteroids are allowed on study as long as
they have been on a stable or weaning dose for 7 days prior to study initiation
(defined as first day of treatment).
Age minimum:
N/A
Age maximum:
21 Years
Gender:
Both
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Health Condition(s) or Problem(s) studied
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Low-grade Gliomas
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Intervention(s)
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Drug: Tarceva and Rapamycin
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Primary Outcome(s)
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Participants will remain on the trial for one year if benefiting from drug as demonstrated by radiographic evaluation and clinical evaluation.
[Time Frame: one year]
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Source(s) of Monetary Support
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Please refer to primary and secondary sponsors
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Results
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Results available:
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Date Posted:
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Date Completed:
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URL:
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