Main
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Note: This record shows only 22 elements of the WHO Trial Registration Data Set. To view changes that have been made to the source record, or for additional information about this trial, click on the URL below to go to the source record in the primary register. |
Register:
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ClinicalTrials.gov |
Last refreshed on:
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12 December 2020 |
Main ID: |
NCT00064337 |
Date of registration:
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08/07/2003 |
Prospective Registration:
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Yes |
Primary sponsor: |
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Public title:
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S0115, High-Dose Melphalan and Autologous Peripheral Stem Cell Transplantation in Treating Patients With Multiple Myeloma or Primary Systemic Amyloidosis
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Scientific title:
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S0115, A Phase II Trial Evaluating Modified High Dose Melphalan (100 mg/m) And Autologous Peripheral Blood Stem Cell Supported Transplant (SCT) For High Risk Patients With Multiple Myeloma And/Or Light Chain Amyloidosis (AL Amyloidosis) (A BMT Study) |
Date of first enrolment:
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January 2004 |
Target sample size:
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104 |
Recruitment status: |
Completed |
URL:
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https://clinicaltrials.gov/show/NCT00064337 |
Study type:
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Interventional |
Study design:
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Allocation: N/A. Intervention model: Single Group Assignment. Primary purpose: Treatment. Masking: None (Open Label).
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Phase:
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Phase 2
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Countries of recruitment
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United States
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Contacts
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Name:
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Vaishali Sanchorawala, MD |
Address:
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Telephone:
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Email:
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Affiliation:
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Boston Medical Center |
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Name:
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David C. Seldin, MD, PhD |
Address:
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Telephone:
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Email:
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Affiliation:
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Boston Medical Center |
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Key inclusion & exclusion criteria
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DISEASE CHARACTERISTICS:
- At least 1 of the following diagnoses:
- Multiple myeloma
- Stage II or III disease
- At least 1 of the following must be present:
- Serum M-protein of IgG, IgA, IgD, IgE greater than 1.0 g/dL
- Urinary M-protein (Bence-Jones) at least 200 mg/24 hours
- No IgM peaks except in patients who have physiologic criteria to support a
diagnosis of multiple myeloma (e.g., bony lesions, myeloma kidney-cast
nephropathy, absence of adenopathy [unless pathology-proven to be plasma
cell infiltration])
- No monoclonal gammopathy of undetermined significance
- No indolent or smoldering myeloma
- No disease progression on prior thalidomide or dexamethasone
- Histologically confirmed primary systemic amyloidosis
- No senile, secondary, localized, dialysis-related, or familial amyloidosis
- No severe cardiac involvement
- No pre-exertional syncope, ventricular arrhythmia, or symptomatic
pleural effusions associated with cardiac involvement
- Light Chain Deposition Disease alone or in combination with multiple myeloma
meeting the following criteria:
- Deposition of granular material containing free light chains/immunoglobulins
that did not bind Congo red
- Evidence of plasma cell dyscrasia (i.e., monoclonal gammopathy in the serum
or urine by immunofixation electrophoresis and/or clonal plasmacytosis) on
bone marrow biopsy by immunohistochemistry and/or elevated serum-free light
chain concentration
- Must have been diagnosed within the past year
- Concurrent enrollment in the myeloma repository protocol SWOG-S0309 must be offered
PATIENT CHARACTERISTICS:
Age
- 18 and over (patients with amyloidosis only OR patients with amyloidosis and multiple
myeloma OR patients with multiple myeloma only with poor renal function) OR
- 70 and over (patients with multiple myeloma only with or without poor renal function)
Performance status
- Zubrod 0-2
Life expectancy
- Not specified
Hematopoietic
- Absolute neutrophil count at least 1,000/mm^3
- Platelet count at least 100,000/mm^3
Hepatic
- Bilirubin no greater than 2.5 times upper limit of normal (ULN)
- SGOT or SGPT no greater than 2.5 times ULN
Renal
- No hemodialysis within 2 hours of melphalan or stem cell infusion
Cardiovascular
- See Disease Characteristics
- Hemodynamically stable (i.e., systolic blood pressure > 90 mm Hg in a lying position
within the past 42 days)
- No myocardial infarction within the past 6 months
- No congestive heart failure
- No arrhythmia refractory to medical therapy
- LVEF greater than 45% by echocardiogram or MUGA
Pulmonary
- See Disease Characteristics
- No history of chronic obstructive or chronic restrictive pulmonary disease
- Pulmonary function studies (e.g., FEV_1 and FVC) at least 50% of predicted
- DLCO at least 50% of predicted
- Normal high resolution CT scan of the chest and acceptable arterial blood gases (i.e.,
PO_2 greater than 70) required for patients unable to complete pulmonary function
tests due to bone pain or fracture
Other
- Not pregnant or nursing
- Negative pregnancy test
- Fertile patients must use effective contraception
- Multiple myeloma patients receiving thalidomide must use 2 methods of effective
contraception for at least 4 weeks before, during, and for at least 4 weeks after
discontinuation of thalidomide
- HIV negative
- No other concurrent significant medical condition
- No concurrent uncontrolled life-threatening infection
- No other malignancy within the past 5 years except adequately treated basal cell or
squamous cell skin cancer, carcinoma in situ of the cervix, or adequately treated
stage I or II cancer currently in complete remission
PRIOR CONCURRENT THERAPY:
Biologic therapy
- See Disease Characteristics
Chemotherapy
- See Disease Characteristics
- Prior cumulative melphalan dose no more than 200 mg
- No other concurrent chemotherapy
Endocrine therapy
- See Disease Characteristics
- No concurrent hormonal therapy
Radiotherapy
- No concurrent radiotherapy
Surgery
- Not specified
Other
- Recovered from prior therapy
- Prior or concurrent bisphosphonates allowed
Age minimum:
18 Years
Age maximum:
120 Years
Gender:
All
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Health Condition(s) or Problem(s) studied
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Plasma Cell Myeloma
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Multiple Myeloma
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Intervention(s)
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Drug: dexamethasone
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Drug: melphalan
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Biological: filgrastim
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Drug: thalidomide
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Drug: cyclophosphamide
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Procedure: peripheral blood stem cell transplantation
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Primary Outcome(s)
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Overall Survival
[Time Frame: 5 years from initial registration, or until death, whichever occurred earlier, on average, about 4.5 years]
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Secondary Outcome(s)
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Hematologic Response
[Time Frame: Until off study]
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Secondary ID(s)
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U10CA032102
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S0115
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Source(s) of Monetary Support
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Please refer to primary and secondary sponsors
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