Main
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Note: This record shows only 22 elements of the WHO Trial Registration Data Set. To view changes that have been made to the source record, or for additional information about this trial, click on the URL below to go to the source record in the primary register. |
Register:
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ClinicalTrials.gov |
Last refreshed on:
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4 January 2016 |
Main ID: |
NCT00002718 |
Date of registration:
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01/11/1999 |
Prospective Registration:
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No |
Primary sponsor: |
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Public title:
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T-cell Depleted Bone Marrow and G-CSF Stimulated Peripheral Stem Cell Transplantation From Related Donors in Treating Patients With Leukemia, Lymphoblastic Lymphoma, Myelodysplastic Syndrome, or Aplastic Anemia
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Scientific title:
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A Phase II Trial of T-Cell Depleted Marrow Grafts Combined With Infusions of G-CSF Stimulated, CD34 Ceprate Stem Cell Column Selected, E-Rosette Depleted Peripheral Blood Progenitor Cells Derived From HLA Haplotype Matched Related Donors for Patients With Leukemia Lacking an HLA-Matched Related or Unrelated Donor |
Date of first enrolment:
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November 1995 |
Target sample size:
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31 |
Recruitment status: |
Completed |
URL:
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https://clinicaltrials.gov/show/NCT00002718 |
Study type:
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Interventional |
Study design:
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Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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Phase:
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Phase 2
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Countries of recruitment
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United States
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Contacts
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Name:
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Richard J. O'Reilly, MD |
Address:
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Telephone:
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Email:
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Affiliation:
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Memorial Sloan Kettering Cancer Center |
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Key inclusion & exclusion criteria
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DISEASE CHARACTERISTICS:
- One of the following diagnoses:
- Acute myelogenous leukemia (AML) meeting 1 of the following conditions:
- Failed to achieve first remission after an intensive induction regimen
containing an anthracycline and cytarabine
- In second remission and not enrolled in a protocol for autologous bone
marrow transplantation
- Failed to achieve or sustain second remission
- In first remission but at high risk of relapse because of 1 of the
following factors:
- High-risk cytogenetic features (monosomy 7,5q-, trisomy 8, or t(9;22))
- AML secondary to treatment of a prior malignancy and without good-risk
cytogenetic features of t(8;21), t(15;17), or inv 16
- AML secondary to myelodysplastic disease
- Acute lymphocytic leukemia (ALL) meeting 1 of the following conditions:
- In second remission with initial relapse occurring within 2 years of
diagnosis
- In first complete remission with high-risk cytogenetics (t(9;22) or
t(4;11))
- In third or subsequent remission
- Failed to achieve or sustain a second remission
- Chronic myelogenous leukemia (CML) in first or second chronic phase or
accelerated phase
- Stage IV lymphoblastic lymphoma not in first remission or that failed to achieve
a remission within the first 4 weeks of induction therapy
- Juvenile CML
- Myelodysplastic syndrome
- Severe aplastic anemia unresponsive to anti-thymocyte globulin or cyclosporine
- No CNS or skin involvement with leukemia
- No requirement for mediastinal irradiation
- No healthy, HLA-identical related donor of at least 1 year of age or matched
unrelated donor available within 4-6 months
- Availability of a healthy, 1-3 HLA-A, -B, and -DR mismatched related donor
- Willing and able to undergo general anesthesia for marrow donation and a 5-day
course of filgrastim (G-CSF) with 2 daily leukaphereses
PATIENT CHARACTERISTICS:
Age:
- Under 50 (50 and over allowed on a case-by-case basis)
Performance status:
- Age 16 and over:
- Karnofsky 70-100%
- Under age 16:
- Lansky 50-100%
Hematopoietic:
- Not specified
Hepatic:
- Bilirubin less than 2.0 mg/dL (in the absence of liver involvement)
- AST less than twice normal (in the absence of liver involvement)
Renal:
- Creatinine normal OR
- Creatinine clearance greater than 60 mL/min
Cardiovascular:
- Asymptomatic or LVEF greater than 50% at rest, with improvement during exercise
Pulmonary:
- Asymptomatic or DLCO greater than 50% predicted (corrected for hemoglobin)
Other:
- No known hypersensitivity to mouse protein or chicken egg products
- No active viral, bacterial, or fungal infection
- HIV-1, HIV-2, HTLV-1, and HTLV-2 negative
- No other concurrent medical condition that would preclude transplantation
- Not pregnant or nursing
PRIOR CONCURRENT THERAPY:
Biologic therapy
- See Disease Characteristics
Chemotherapy
- See Disease Characteristics
Endocrine therapy
- Not specified
Radiotherapy
- See Disease Characteristics
Surgery
- See Disease Characteristics
Age minimum:
N/A
Age maximum:
49 Years
Gender:
Both
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Health Condition(s) or Problem(s) studied
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Leukemia
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Myelodysplastic Syndromes
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Lymphoma
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Myelodysplastic/Myeloproliferative Neoplasms
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Intervention(s)
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Drug: methylprednisolone
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Procedure: in vitro-treated bone marrow transplantation
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Biological: anti-thymocyte globulin
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Radiation: radiation therapy
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Drug: cyclophosphamide
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Procedure: in vitro-treated peripheral blood stem cell transplantation
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Biological: filgrastim
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Drug: thiotepa
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Drug: cytarabine
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Primary Outcome(s)
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overall disease survival
[Time Frame: 2 to 4 years post transplant]
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Secondary Outcome(s)
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To correlate progenitor cell doses and doses of clonable T-cells
[Time Frame: 2 years]
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Secondary ID(s)
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95-084
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P30CA008748
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MSKCC-95084
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NCI-V96-0809
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Source(s) of Monetary Support
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Please refer to primary and secondary sponsors
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Results
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Results available:
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Date Posted:
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Date Completed:
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URL:
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