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Main
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Note: This record shows only 22 elements of the WHO Trial Registration Data Set. To view changes that have been made to the source record, or for additional information about this trial, click on the URL below to go to the source record in the primary register. |
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Register:
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ChiCTR |
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Last refreshed on:
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24 January 2022 |
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Main ID: |
ChiCTR1900027197 |
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Date of registration:
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2019-11-04 |
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Prospective Registration:
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No |
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Primary sponsor: |
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Public title:
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Study on the protective effect of desflurane combined with propofol on the brain of patients with moyamoya disease undergoing cerebral revascularization
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Scientific title:
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Study for the protective effect of desflurane on the brain of patients with moyamoya disease |
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Date of first enrolment:
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2019-05-01 |
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Target sample size:
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Group D:30;GroupP:30;GroupPD:30; |
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Recruitment status: |
Completed |
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URL:
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http://www.chictr.org.cn/showproj.aspx?proj=44942 |
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Study type:
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Interventional study |
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Study design:
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Parallel
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Phase:
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4
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Countries of recruitment
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China
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Contacts
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Name:
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Wang Zhongyu
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Address:
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1 Jianshe Road East, Erqi District, Zhengzhou, He'nan, China
450052
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Telephone:
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+86 13937165514 |
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Email:
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wzy781217@163.com |
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Affiliation:
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The First Affiliated Hospital of Zhengzhou University |
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Name:
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Feng Fengxi
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Address:
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1 Jianshe Road East, Erqi District, Zhengzhou, He'nan, China
450052
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Telephone:
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+86 13849030473 |
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Email:
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756023673@qq.com |
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Affiliation:
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The First Affiliated Hospital of Zhengzhou University |
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Key inclusion & exclusion criteria
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Inclusion criteria: Aged 20-65 years; BMI 18-25kg/m2; ASA I-II grade; patients without hypertension or with hypertension history and satisfactory blood pressure control; patients without diabetes or with diabetes history and satisfactory blood glucose control.Hemoglobin (HB) >= 100g / L, hematocrit (HCT) >= 30%; no coagulation dysfunction, no long-term history of antidepressant and analgesic drugs
Exclusion criteria: Patient or his family refused to sign the informed consent form and patients with liver and kidney function abnormality, lung function abnormality, serious coronary heart disease, serious endocrine disease, mental disease, drug abuse, coagulation function abnormality, unconsciousness, organ intubation difficulty, and severe fluctuation of hemodynamics during operation.
Age minimum:
20
Age maximum:
65
Gender:
Both
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Health Condition(s) or Problem(s) studied
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Moyamoya disease
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Intervention(s)
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Group D:Desflurane for anesthesia maintenance;GroupP:Propofol;GroupPD:Desflurane and propofol;
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Primary Outcome(s)
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Artefiovenous oxygen content difference;Cerebral oxygen extraction rate;Jugular venous blood oxygen saturation;Complication;GluERMB;LacPR;LOI;mRS score;NSE;S100ß protein;
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Secondary Outcome(s)
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Mean arterial pressure;
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Source(s) of Monetary Support
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self-financing
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Ethics review
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Status: Approved
Approval date: 26/04/2019
Contact:
Tian Li
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Results
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Results available:
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Date Posted:
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Date Completed:
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URL:
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