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Main
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Note: This record shows only 22 elements of the WHO Trial Registration Data Set. To view changes that have been made to the source record, or for additional information about this trial, click on the URL below to go to the source record in the primary register. |
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Register:
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ChiCTR |
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Last refreshed on:
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4 December 2018 |
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Main ID: |
ChiCTR1800019833 |
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Date of registration:
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2018-12-02 |
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Prospective Registration:
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Yes |
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Primary sponsor: |
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Public title:
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Dynamic changes of TCM syndrome types of idiopathic membranous nephropathy treated with cyclophosphamide combined with hormone
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Scientific title:
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Dynamic changes of TCM syndrome types of idiopathic membranous nephropathy treated with cyclophosphamide combined with hormone |
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Date of first enrolment:
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2019-01-01 |
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Target sample size:
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PLA2R???:30;PLA2R positive Group:30; |
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Recruitment status: |
Pending |
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URL:
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http://www.chictr.org.cn/showproj.aspx?proj=33364 |
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Study type:
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Observational study |
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Study design:
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Cohort study
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Phase:
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Pilot study
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Countries of recruitment
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China
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Contacts
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Name:
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Hong Bo Chen
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Address:
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54 Youdian Road, Shangcheng District, Hangzhou, Zhejiang, China
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Telephone:
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+86 0571-86008671 |
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Email:
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chenhb521@126.com |
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Affiliation:
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Department of Nephrology, The First Affiliated Hospital of Zhejiang Chinese Medical University |
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Name:
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Wen Zhang
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Address:
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54 Youdian Road, Shangcheng District, Hangzhou, Zhejiang, China
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Telephone:
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+86 13758118936 |
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Email:
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306762827@qq.com |
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Affiliation:
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Department of Nephrology, The First Affiliated Hospital of Zhejiang Chinese Medical University |
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Key inclusion & exclusion criteria
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Inclusion criteria: (1) aged 18-85 years old;
(2) meet the diagnostic criteria of nephrotic syndrome;
(3) renal biopsy showed idiopathic membranous nephropathy.
Exclusion criteria: (1) exclude acute renal failure, renal function stage 3, stage 4 patients;
(2) patients with serious primary diseases such as heart, brain, liver or hematopoietic system;
(3) excluding lupus, hepatitis b, diabetes and other secondary membranous nephropathy;
(4) have a history of mental illness;
(5) patients who did not agree to be included in the study.
Age minimum:
18
Age maximum:
85
Gender:
Male
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Health Condition(s) or Problem(s) studied
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Idiopathic Membranous Nephropathy
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Intervention(s)
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PLA2R???:Cyclophosphamide combined with hormone therapy ;PLA2R positive Group:Cyclophosphamide combined with hormone therapy;
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Primary Outcome(s)
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PLA2R;THSD7A;Routine blood;Serum creatinine;Blood urea nitrogen;cholesterol;Serum albumin;TCM syndrome type dialectics;TCM syndrome score;Urine protein quantification for 24 hours;
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Secondary Outcome(s)
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Glutamate transaminase;Glutamate transaminase;
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Source(s) of Monetary Support
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Natural Science Foundation of Zhejiang Province
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Ethics review
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Status: Approved
Approval date: 15/05/2018
Contact:
Fang Hu
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Results
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Results available:
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Date Posted:
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Date Completed:
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URL:
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