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Main
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Note: This record shows only 22 elements of the WHO Trial Registration Data Set. To view changes that have been made to the source record, or for additional information about this trial, click on the URL below to go to the source record in the primary register. |
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Register:
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ChiCTR |
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Last refreshed on:
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29 January 2018 |
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Main ID: |
ChiCTR1800014542 |
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Date of registration:
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2018-01-20 |
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Prospective Registration:
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Yes |
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Primary sponsor: |
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Public title:
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Up-down sequential testing of propofol - induced half-effective dose ( ed50 ) in patients with Parkinson's disease and non - Parkinson's disease
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Scientific title:
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Up-down sequential testing of propofol - induced half-effective dose ( ed50 ) in patients with Parkinson's disease and non - Parkinson's disease |
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Date of first enrolment:
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2018-01-22 |
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Target sample size:
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PD group:40;NPD group:40; |
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Recruitment status: |
Recruiting |
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URL:
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http://www.chictr.org.cn/showproj.aspx?proj=24702 |
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Study type:
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Relative factors research |
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Study design:
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Case-Control study
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Phase:
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Other
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Countries of recruitment
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China
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Contacts
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Name:
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WANG PING
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Address:
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45 Changchun Street, Xicheng District, Beijing, China
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Telephone:
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+86 18501306236 |
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Email:
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1543842004@qq.com |
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Affiliation:
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Xuanwu Hospital of CCMU |
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Name:
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ZHAO LEI
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Address:
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45 Changchun Street, Xicheng District, Beijing, China
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Telephone:
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+86 13811035886 |
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Email:
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zhaoalei@sina.com |
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Affiliation:
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Xuanwu Hospital of CCMU |
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Key inclusion & exclusion criteria
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Inclusion criteria: 1. ASA grades I-II;
2. Age 18 - 65 years;
3. BMI< 35;
4. No severe respiratory and circulatory diseases;
5. Patients signed informed consent, and approved by the hospital ethics Committee, etc.
Pd: diagnosis of Parkinson's disease during hospitalization, selective DBS treatment, in line with surgical indications (excluding dementia, etc.);
Exclusion criteria: 1. Patients allergic to propofol;
2. Lipids metabolism disorder;
3. Alcoholics;
4. Patients with bis of less than 80 when entering operating room;
5. After induction, the mean arterial pressure decreased by more than 20 %
6. Patients with severe respiratory and circulatory diseases.
Age minimum:
18
Age maximum:
65
Gender:
Both
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Health Condition(s) or Problem(s) studied
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Parkinson's Disease
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Intervention(s)
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PD group:propofol;NPD group:propofol;
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Primary Outcome(s)
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BIS value;
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Secondary Outcome(s)
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age;gender;Body Mass Index;state of consciousness before operation;Blood pressure;MAP;HR;SpO2;PET CO2;temperature;ASA status;NYHA functional class;MET class;complication of other systems;length of surgery;infusion volume;lost volume;whether extubation;postoperative consciousness;postoperative whereabouts;hospital stay;
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Source(s) of Monetary Support
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Support was received solely from institutional sources
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Ethics review
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Status: Not approved
Approval date: 26/08/2013
Contact:
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Results
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Results available:
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Date Posted:
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Date Completed:
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URL:
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