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Main
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Note: This record shows only 22 elements of the WHO Trial Registration Data Set. To view changes that have been made to the source record, or for additional information about this trial, click on the URL below to go to the source record in the primary register. |
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Register:
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ChiCTR |
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Last refreshed on:
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18 April 2017 |
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Main ID: |
ChiCTR-ONC-12002809 |
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Date of registration:
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2012-05-24 |
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Prospective Registration:
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No |
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Primary sponsor: |
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Public title:
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Clinical Study of Prediction of Glucocorticoid Efficacy by cytokins in Patients with Primary Nephrotic Syndrome
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Scientific title:
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Clinical Study of Prediction of Glucocorticoid Efficacy by cytokins in Patients with Primary Nephrotic Syndrome |
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Date of first enrolment:
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2009-01-01 |
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Target sample size:
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1:90; |
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Recruitment status: |
Completed |
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URL:
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http://www.chictr.org.cn/showproj.aspx?proj=6745 |
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Study type:
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Observational study |
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Study design:
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historical control
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Phase:
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Other
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Countries of recruitment
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China
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Contacts
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Name:
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Lin Hong-li
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Address:
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222 Zhongshan Road, Dalian
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Telephone:
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+86 13332268576 |
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Email:
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linhongli@vip.163.com |
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Affiliation:
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The First Affiliated Hospital of Dalian Medical University |
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Name:
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Xie Hua
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Address:
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222 Zhongshan Road, Dalian
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Telephone:
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+86 15541191277 |
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Email:
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wlciq007@163.com |
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Affiliation:
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Key inclusion & exclusion criteria
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Inclusion criteria: (1) >=18years old;
(2) Primary nephrotic syndrome and no application of glucocorticoid or immunosuppressive agents;
(3) Blood pressure can effectively control less than 130/80mmHg or without hypertension;
(4) Taking an ARB or ACEI drugs more than four weeks;
(5) Serum creatinine level <=200umol/L;
(6) Routine renal biopsy.
Exclusion criteria: (1) All kinds of secondary nephrotic syndrome, such as lupus nephritis, Henoch-Schonlein purpura nephritis, diabetic nephropathy, hypertensive nephropathy and so on;
(2) BMI between <=18 or >=25;
(3) Urine protein quantitative maitains 0.3-3g/24h after prescription with glucocorticoid 8 weeks;
(4) The patients participating the other trials;
(5) Researchers consider the patients not suitable for clinical trials.
Age minimum:
18
Age maximum:
75
Gender:
Both
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Health Condition(s) or Problem(s) studied
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Idiopathic nephrotic syndrome
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Intervention(s)
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1:Given methylprednisolone according to the status of the patients ;
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Primary Outcome(s)
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Cytokines Level;
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Secondary Outcome(s)
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Cumulative remission;Serum creatinine;eGFR;Serum albumin;24h Urine protein quantity;
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Source(s) of Monetary Support
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Grant from the National Basic Research Program of China (No. 2011CB944000).
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Results
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Results available:
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Date Posted:
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Date Completed:
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URL:
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