The study on early diagnosis of Parkinson 's disease by transcranial ultrasonography

• Register: ChiCTR
• Last refreshed on: 18 April 2017
• Main ID: ChiCTR-DDD-17010794
• Date of registration: 2017-03-05
• Prospective Registration: No
• Primary sponsor: Department of Neurology, Fujian Institute of Geriatrics, Fujian Medical University Union Hospital
• Public title: The study on early diagnosis of Parkinson 's disease by transcranial ultrasonography
• Scientific title: the study on early diagnosis of Parkinson 's disease by transcranial ultrasonography
• Date of first enrolment: 2014-11-08
• Target sample size: Target condition:135;Difficult condition:0
• Recruitment status: Completed
• URL: http://www.chictr.org.cn/showproj.aspx?proj=18272
• Study type: Diagnostic test
• Study design: Diagnostic test for accuracy
• Phase: Diagnostic New Technique Clincal Study

Countries of recruitment

China

Contacts

• Name: Qinyong Ye
• Affiliation: Department of Neurology, Fujian Institute of Geriatrics, Fujian Medical University Union Hospital

• Name: Qinyong Ye
• Affiliation: Department of Neurology, Fujian Institute of Geriatrics, Fujian Medical University Union Hospital

Key inclusion & exclusion criteria

Inclusion criteria: 67 Parkinson's disease patients in our research came from Department of Neurology, Fujian Medical University Union Hospital. They were diagnosed by Queen Square Brain Bank UK PDS Brain Bank Criteria for the diagnosis of PD as the case group. Their ages were ranged from 36 to 84 years old, the average age was (67.18 ± 9.912) years old. All PD patients underwent UPDRS-III, and Hoehn-Yahr Rating Scale (H-Y). The UPDRS results can be divided into mild (below 10 points), moderate (11-20), severe (21-30).
Exclusion criteria: In this research, 68 participants, without family history of PD and ruling out Parkinson’syndrome, Vascular Parkinsonism and the other extrapyramidal disease, were recruited as the control group. The both groups matched in age and gender.

Age minimum: 36
Age maximum: 84
Gender: Both

Health Condition(s) or Problem(s) studied

Parkinson's Disease

Intervention(s)

Gold Standard:Diagnosis of Parkinson disease needs to meet 3 or more: unilateral onset;resting tremor;progressive course; long term asymmetry, the most obvious symptoms is the onset side; a good response to levodopa (70% ~ 100%); levodopa induced chorea; a reaction of levodopa lasts 5 years or more; clinical course last;Index test:Laboratory apparatus
As shown in Figure 1, The ultrasound equipment, Philips IE33-BOMJH1 color Doppler ultrasonography, Model IE-ELite, with 2-4MHz phased array probe (S5-1 probe) was used for TCS to examine SN in our study.
Transcranial ultrasound study
Ultrasonography through temporal window, alon;

Primary Outcome(s)

the area of the echogenic signals in the substantia nigra;the intensity of the echogenic signals in the substantia nigra;

Source(s) of Monetary Support

the National Natural Science Foundation of China (General Program)