This inventory summarizes evaluations of pesticides that have been performed by the Joint FAO/WHO Meeting on Pesticide Residues (JMPR). It does not include the maximum residue levels (MRLs) that have been recommended by JMPR.
Maximum residue limits adopted by Codex Alimentarius Commission are available on: https://www.fao.org/fao-who-codexalimentarius/codex-texts/dbs/pestres/tr/
The most up-to-date information concerning JMPR meetings, reports and toxicological monographs is available at: Joint FAO/WHO Meeting on Pesticide Residues (JMPR)
MANDIPROPAMID
General Information
| CAS number: | 374726-62-2 |
| Chemical Class: | |
| Use: | fungicide |
Evaluations
| Year |
ADI (mg/kg bw) |
ARfD (mg/kg bw) |
Comments | Documents |
|---|---|---|---|---|
| 2022 | Mandipropamid is being evaluated by the current JMPR following a request from CCPR for additional MRLs on potatoes. The studies provided would have had no effect on the HBGVs , so they were not reviewed by this Meeting. |
Report : JMPR 2022 - Report |
||
| 2018 | 0–0.2 | Unnecessary | A 90-day feeding study in mice, an immunotoxicity study in mice and several mechanistic studies performed with the parent compound were submitted. In addition, a number of toxicological and genotoxicity studies with the metabolite (4-chlorophenyl)-prop-2-ynyloxy-acetic acid (SYN500003) were provided. For the metabolite SYN500003, the ADI for mandipropamid is not applicable, as the metabolite is structurally different from the parent and is more acutely toxic. No separate ADI or ARfD can be established for the metabolite, as the database is not sufficient for this purpose. For chronic toxicity, the TTC concept for non-genotoxic substances (Cramer class III) is applicable to this metabolite. |
Report : JMPR_2018 Report.pdf Tox Monograph : MANDIPROPAMID_add_2018.pdf |
| 2008 | 0-0.2 | UNNECESSARY |
Tox Monograph : MANDIPROPAMID.pdf Report : JMPR_2008_report.pdf |