WHO Model Prescribing Information: Drugs Used in Skin Diseases
(1997; 132 pages) [French] [Spanish] Voir le document au format PDF
Table des matières
Afficher le documentPreface
Afficher le documentIntroduction
Ouvrir ce répertoire et afficher son contenuParasitic infections
Ouvrir ce répertoire et afficher son contenuInsect and arachnid bites and stings
Ouvrir ce répertoire et afficher son contenuSuperficial fungal infections
Ouvrir ce répertoire et afficher son contenuSubcutaneous fungal infections
Ouvrir ce répertoire et afficher son contenuBacterial infections
Ouvrir ce répertoire et afficher son contenuViral infections
Ouvrir ce répertoire et afficher son contenuEczematous diseases
Ouvrir ce répertoire et afficher son contenuScaling diseases
Fermer ce répertoirePapulosquamous diseases
Afficher le documentLichen planus
Afficher le documentPityriasis rosea
Afficher le documentPsoriasis
Afficher le documentCutaneous reactions to drugs
Ouvrir ce répertoire et afficher son contenuPigmentary disorders
Ouvrir ce répertoire et afficher son contenuPremalignant lesions and malignant tumours
Ouvrir ce répertoire et afficher son contenuPhotodermatoses
Ouvrir ce répertoire et afficher son contenuBullous dermatoses
Afficher le documentAlopecia areata
Afficher le documentUrticaria
Ouvrir ce répertoire et afficher son contenuConditions common in children
Afficher le documentAcne vulgaris
Afficher le documentPruritus
Afficher le documentTropical ulcers
Ouvrir ce répertoire et afficher son contenuAntimicrobial drugs
Ouvrir ce répertoire et afficher son contenuAntifugal drugs
Ouvrir ce répertoire et afficher son contenuAntiseptic agents
Ouvrir ce répertoire et afficher son contenuKeratoplastic and keratolytic agents
Ouvrir ce répertoire et afficher son contenuScabicides and pediculicides
Ouvrir ce répertoire et afficher son contenuAnti-inflammatory and antipruritic drugs1
Ouvrir ce répertoire et afficher son contenuAntiallergics and drugs used in anaphylaxis
Ouvrir ce répertoire et afficher son contenuUltraviolet radiation-blocking agents (sunscreens)
Ouvrir ce répertoire et afficher son contenuMiscellaneous drugs
Ouvrir ce répertoire et afficher son contenuAnnex
Afficher le documentSelected WHO Publications of Related Interest
Afficher le documentBack cover
 

Lichen planus

Lichen planus is a chronic, papular, pruritic skin eruption that occurs typically in middle age and later life. In some tropical countries, where it affects up to 2% of the population, it may be more common in children and in some instances related to exposure to the sun. Sometimes it is induced by drugs, including chloroquine, streptomycin, amiphenazole, quinidine and gold salts. In most cases, however, there is no obvious cause.

The lesions appear as flat-topped, polygonal, shiny papules, that in light-skinned patients are violet-coloured and, in darker patients, greyish or dark brown. They may occur anywhere, but are commonly found on the flexor surfaces of the wrists, the lumbar region, the genitalia and the lower legs. Older lesions, particularly on the legs, are thickened and may have more scales. Healing, which may not occur for many years, often leaves the skin deeply pigmented. The mucous membranes of the oral cavity may also be involved, and when ulceration occurs, it is important to rule out the possibility of an oral malignancy.

Management

The condition is often mild and may need no treatment or only the use of low-potency topical corticosteroids. Hypertrophic lesions are best treated with topical corticosteroids under occlusive dressings, but treatment with oral corticosteroids such as prednisolone may be needed when large areas of skin or the mucous membranes are involved. Retinoids are also claimed to be useful, but the large doses required are potentially toxic, and the more potent derivatives, such as isotretinoin, tretinoin and etretinate, are proven teratogens.

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