Stability of Oral Oxytocics in Tropical Climates - Results of Simulation Studies on Oral Ergometrine, Oral Methylergometrine, Buccal Oxytocin and Buccal Desamino-Oxytocin - EDM Research Series No. 012
(1994; 52 pages) Ver el documento en el formato PDF
Índice de contenido
Ver el documentoAbbreviations
Ver el documentoSummary
Abrir esta carpeta y ver su contenidoIntroduction
Abrir esta carpeta y ver su contenidoMaterials and methods
Cerrar esta carpetaResults
Ver el documentoErgometrine (E)
Ver el documentoMethylergometrine (ME)
Ver el documentoOxytocin (OT)
Ver el documentoDesamino-oxytocin (DOT)
Abrir esta carpeta y ver su contenidoDiscussion
Ver el documentoConclusions and recommendations
Ver el documentoReferences
Abrir esta carpeta y ver su contenidoAnnexes
 

Ergometrine (E)

The level of active ingredient in the product decreased over time under all conditions. Under refrigerated storage (D6/83) the level of active ingredient remained above 90% for 3 weeks. After that it no longer met pharmaceutical requirements. At D40/75 ergometrine was very unstable, with only 26.5% of the active ingredient left after 3 weeks, and 1% after 52 weeks of exposure (Figure 1).

The influence of humidity on stability is stronger than the influence of temperature (Figure 2). After 21 weeks at 30°C in darkness and 75%RH (D30/75), the product had only 24% of the stated amount of the active ingredient. Exposed to D40/25 for 52 weeks, 44.9% of the stated amount of active ingredient remained. The influence of light seems less harmful than that of humidity (Figure 3).

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