WHO Model Prescribing Information: Drugs Used in Skin Diseases
(1997; 132 pages) [French] [Spanish] Ver el documento en el formato PDF
Índice de contenido
Ver el documentoPreface
Ver el documentoIntroduction
Abrir esta carpeta y ver su contenidoParasitic infections
Abrir esta carpeta y ver su contenidoInsect and arachnid bites and stings
Abrir esta carpeta y ver su contenidoSuperficial fungal infections
Abrir esta carpeta y ver su contenidoSubcutaneous fungal infections
Abrir esta carpeta y ver su contenidoBacterial infections
Abrir esta carpeta y ver su contenidoViral infections
Abrir esta carpeta y ver su contenidoEczematous diseases
Abrir esta carpeta y ver su contenidoScaling diseases
Cerrar esta carpetaPapulosquamous diseases
Ver el documentoLichen planus
Ver el documentoPityriasis rosea
Ver el documentoPsoriasis
Ver el documentoCutaneous reactions to drugs
Abrir esta carpeta y ver su contenidoPigmentary disorders
Abrir esta carpeta y ver su contenidoPremalignant lesions and malignant tumours
Abrir esta carpeta y ver su contenidoPhotodermatoses
Abrir esta carpeta y ver su contenidoBullous dermatoses
Ver el documentoAlopecia areata
Ver el documentoUrticaria
Abrir esta carpeta y ver su contenidoConditions common in children
Ver el documentoAcne vulgaris
Ver el documentoPruritus
Ver el documentoTropical ulcers
Abrir esta carpeta y ver su contenidoAntimicrobial drugs
Abrir esta carpeta y ver su contenidoAntifugal drugs
Abrir esta carpeta y ver su contenidoAntiseptic agents
Abrir esta carpeta y ver su contenidoKeratoplastic and keratolytic agents
Abrir esta carpeta y ver su contenidoScabicides and pediculicides
Abrir esta carpeta y ver su contenidoAnti-inflammatory and antipruritic drugs1
Abrir esta carpeta y ver su contenidoAntiallergics and drugs used in anaphylaxis
Abrir esta carpeta y ver su contenidoUltraviolet radiation-blocking agents (sunscreens)
Abrir esta carpeta y ver su contenidoMiscellaneous drugs
Abrir esta carpeta y ver su contenidoAnnex
Ver el documentoSelected WHO Publications of Related Interest
Ver el documentoBack cover
 

Lichen planus

Lichen planus is a chronic, papular, pruritic skin eruption that occurs typically in middle age and later life. In some tropical countries, where it affects up to 2% of the population, it may be more common in children and in some instances related to exposure to the sun. Sometimes it is induced by drugs, including chloroquine, streptomycin, amiphenazole, quinidine and gold salts. In most cases, however, there is no obvious cause.

The lesions appear as flat-topped, polygonal, shiny papules, that in light-skinned patients are violet-coloured and, in darker patients, greyish or dark brown. They may occur anywhere, but are commonly found on the flexor surfaces of the wrists, the lumbar region, the genitalia and the lower legs. Older lesions, particularly on the legs, are thickened and may have more scales. Healing, which may not occur for many years, often leaves the skin deeply pigmented. The mucous membranes of the oral cavity may also be involved, and when ulceration occurs, it is important to rule out the possibility of an oral malignancy.

Management

The condition is often mild and may need no treatment or only the use of low-potency topical corticosteroids. Hypertrophic lesions are best treated with topical corticosteroids under occlusive dressings, but treatment with oral corticosteroids such as prednisolone may be needed when large areas of skin or the mucous membranes are involved. Retinoids are also claimed to be useful, but the large doses required are potentially toxic, and the more potent derivatives, such as isotretinoin, tretinoin and etretinate, are proven teratogens.

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