WHO Handbook for Guideline Development – 2nd Edition
(2014; 179 pages)


This handbook provides detailed instructions for guideline developers on the following topics:

  • application of high quality methodology for guideline development using systematic search strategies, synthesis and quality assessment of the best available evidence to support the recommendations;
  • appropriate collection and management of experts’ declared conflict of interest;
  • expert group composition including content experts, methodologists, target users, policy makers, with gender and geographical balance;
  • instructions for the management of group process to achieve consensus among experts;
  • standards for a transparent decision-making process, taking into consideration potential harms and benefits, end users values and preferences;
  • developing plans for implementing and adapting guidelines; and minimum standards for reporting.
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