Stability of Oral Oxytocics in Tropical Climates - Results of Simulation Studies on Oral Ergometrine, Oral Methylergometrine, Buccal Oxytocin and Buccal Desamino-Oxytocin - EDM Research Series No. 012
(1994; 52 pages) View the PDF document
Table of Contents
View the documentAbbreviations
View the documentSummary
Open this folder and view contentsIntroduction
Open this folder and view contentsMaterials and methods
Close this folderResults
View the documentErgometrine (E)
View the documentMethylergometrine (ME)
View the documentOxytocin (OT)
View the documentDesamino-oxytocin (DOT)
Open this folder and view contentsDiscussion
View the documentConclusions and recommendations
View the documentReferences
Open this folder and view contentsAnnexes

Ergometrine (E)

The level of active ingredient in the product decreased over time under all conditions. Under refrigerated storage (D6/83) the level of active ingredient remained above 90% for 3 weeks. After that it no longer met pharmaceutical requirements. At D40/75 ergometrine was very unstable, with only 26.5% of the active ingredient left after 3 weeks, and 1% after 52 weeks of exposure (Figure 1).

The influence of humidity on stability is stronger than the influence of temperature (Figure 2). After 21 weeks at 30°C in darkness and 75%RH (D30/75), the product had only 24% of the stated amount of the active ingredient. Exposed to D40/25 for 52 weeks, 44.9% of the stated amount of active ingredient remained. The influence of light seems less harmful than that of humidity (Figure 3).

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