(1997; 132 pages) [French] [Spanish]
Fluorouracil is a fluorinated pyrimidine antagonist which acts by interfering with DNA synthesis. Systemic absorption following topical application appears to be insignificant.
• actinic keratosis
• genital warts that fail to respond to treatment with either podophyllum resin or podophyllotoxin.
Dosage and administration
Adults and children: a thin layer of ointment should be applied to the affected area once or twice daily. Treatment should be continued until there is a marked inflammatory response. The usual duration of treatment is 3-4 weeks, but the degree of reaction may be such that therapy can be shortened. Complete healing may not occur until 2 months after cessation of therapy. The rate of healing can be improved by the use of a topical corticosteroid such as hydrocortisone, 1% cream.
Known hypersensitivity to fluorouracil.
If the affected area does not respond to fluorouracil therapy, a biopsy should be taken to confirm the diagnosis and rule out the possibility that there is a basal cell or squamous cell carcinoma.
Care should be taken to avoid contact with the mucous membranes and eyes.
Since exposure to ultraviolet light intensifies the inflammatory reaction, prolonged exposure to sunlight should be avoided during treatment.
Local inflammatory reactions including swelling, scaling, a burning sensation, pain and hyperpigmentation are part of the therapeutic response.
Ointment should be stored in well-closed containers below 30 °C.