(1997; 132 pages) [French] [Spanish]
Ointment or cream, 0.1% (as valerate)
Betamethasone is a topical corticosteroid preparation of high potency. Its therapeutic effects result from vasoconstriction, reduction of membrane permeability, and suppression of mitotic activity and the immune response.
Short-term treatment of non-infectious dermatoses (including contact, atopic and seborrhoeic dermatitis, psoriasis and actinic prurigo).
Dosage and administration
Adults and children over 2 years: a thin layer of ointment should be applied to the affected area twice or three times daily. The frequency of application is gradually reduced as improvement occurs.
• Known hypersensitivity to corticosteroids.
• Infections of the skin.
• Age under 2 years.
Prolonged therapy or treatment of large areas of skin should be avoided as adrenal suppression can occur.
Betamethasone should not be used on the face for more than 7 consecutive days.
If secondary infection occurs during treatment, betamethasone should be withdrawn and an appropriate antimicrobial given.
Use in pregnancy
Betamethasone should not be used in large amounts or for more than 2 weeks during pregnancy.
Existing infections may be exacerbated.
Prolonged use can induce atrophy of the skin, particularly on the face and in skin-folds. This is characterized by thinning of the dermis, depigmentation, dilatation of superficial blood vessels and formation of striae.
Infants and young children are particularly susceptible to the local and systemic effects of topical corticosteroids. Prolonged use can result in hypercorticalism and suppression of the hypothalamic-pituitary-adrenal axis.
Cream and ointment should be stored in well-closed containers.