(1997; 132 pages) [French] [Spanish]
Cream, lotion or powder, 0.3%
Lindane is a cyclic chlorinated hydrocarbon that is toxic to Sarcoptes scabiei, Pediculus humanus capitis, P. humanus corporis and Pthirus pubis. However, resistance to lindane has been reported in certain strains of P. humanus capitis in some countries.
Lindane is slowly and incompletely absorbed following topical application. Absorption is enhanced when it is applied to the face, scalp, neck, axillae, scrotum or damaged or occluded skin. It is metabolized in the liver and slowly excreted in the urine.
Treatment of scabies and pediculosis of the scalp, body and pubic region.
Dosage and administration
All doses are suitable for adults and children over 10 years.
The lotion should be applied to all skin surfaces, excluding the head. It should be rinsed off after 24 hours.
Pediculus humanus capitis:
The lotion should be massaged into the scalp and hair and left for at least 12 hours before rinsing.
Household contacts should be treated at the same time. All combs and brushes should be soaked in a pediculicidal solution (see Parasitic infections - Prevention and management) for at least 2 hours.
Pediculus humanus corporis:
The body should be dusted with the powder. Clothes should be treated at the same time and subsequently washed in boiling water. If this is impractical, they should be left outside exposed to the air for 72 hours.
The lotion should be applied to the hair and skin of the pubic area and left for at least 12 hours before rinsing. If necessary, the thighs, axillae, trunk and head (including the eyebrows) should also be treated. Sexual partners should be treated simultaneously.
No more than 30 g of the lotion should be applied on any one occasion.
• Known hypersensitivity.
• Age under 10 years.
Seizures have been reported with concentrations higher than 0.3%.
Care should be taken to avoid contact with the face, eyes and mucous membranes.
Use in pregnancy
Lindane has been shown to cause fetal toxicity in animal studies. It should not be used during pregnancy.
Local irritation can occur. Repeated applications may cause contact dermatitis. Prolonged extensive application of lindane can cause restlessness, muscle spasms, convulsions and ultimately coma. Death may occur from subsequent respiratory failure.
Gastric lavage is of value when undertaken within a few hours of accidental ingestion or systemic absorption. Convulsions should be treated with intravenous diazepam. Treatment is otherwise supportive.
Preparations should be stored in well-closed containers.