WHO Model Prescribing Information: Drugs Used in Skin Diseases
(1997; 132 pages) [French] [Spanish] View the PDF document
Table of Contents
View the documentPreface
View the documentIntroduction
Open this folder and view contentsParasitic infections
Open this folder and view contentsInsect and arachnid bites and stings
Open this folder and view contentsSuperficial fungal infections
Open this folder and view contentsSubcutaneous fungal infections
Open this folder and view contentsBacterial infections
Open this folder and view contentsViral infections
Open this folder and view contentsEczematous diseases
Open this folder and view contentsScaling diseases
Open this folder and view contentsPapulosquamous diseases
View the documentCutaneous reactions to drugs
Open this folder and view contentsPigmentary disorders
Open this folder and view contentsPremalignant lesions and malignant tumours
Open this folder and view contentsPhotodermatoses
Open this folder and view contentsBullous dermatoses
View the documentAlopecia areata
View the documentUrticaria
Open this folder and view contentsConditions common in children
View the documentAcne vulgaris
View the documentPruritus
View the documentTropical ulcers
Open this folder and view contentsAntimicrobial drugs
Open this folder and view contentsAntifugal drugs
Open this folder and view contentsAntiseptic agents
Close this folderKeratoplastic and keratolytic agents
View the documentBenzoyl peroxide
View the documentCoal tar
View the documentDithranol
View the documentSalicylic acid
View the documentTretinoin
Open this folder and view contentsScabicides and pediculicides
Open this folder and view contentsAnti-inflammatory and antipruritic drugs1
Open this folder and view contentsAntiallergics and drugs used in anaphylaxis
Open this folder and view contentsUltraviolet radiation-blocking agents (sunscreens)
Open this folder and view contentsMiscellaneous drugs
Open this folder and view contentsAnnex
View the documentSelected WHO Publications of Related Interest
View the documentBack cover
 

Benzoyl peroxide

Cream or lotion, 2.5%, 5%, 10%

General information

Benzoyl peroxide is a bacteriostatic agent that is used primarily in acne because of its activity against Propionibacterium acnes.

It is absorbed by the skin after topical application and metabolized to benzoic acid.

Clinical information

Uses

Treatment of mild to moderate acne vulgaris and as an adjunct to therapy in more severe cases.

Dosage and administration

Adults and adolescents: a thin layer of 2.5% or 5% cream or lotion should be applied to clean skin initially once daily on alternate days. The frequency of application is then gradually increased up to twice daily as tolerance develops. Unresponsive cases may require treatment with the 10% preparation.

Contraindications

Known hypersensitivity to benzoyl peroxide.

Precautions

Benzoyl peroxide should not be applied to open sores or broken skin. Contact with the eyes and mucous membranes should be avoided.

Use in pregnancy

Topically applied benzoyl peroxide is not systemically absorbed and can be used safely during pregnancy.

Adverse effects

Skin irritation is common after topical application but subsides with continued treatment.

Rarely, contact sensitivity has been reported.

Storage

Preparations should be stored in well-closed containers. They should not be allowed to freeze.

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