WHO Model Prescribing Information: Drugs Used in Skin Diseases
(1997; 132 pages) [French] [Spanish] View the PDF document
Table of Contents
View the documentPreface
View the documentIntroduction
Open this folder and view contentsParasitic infections
Open this folder and view contentsInsect and arachnid bites and stings
Open this folder and view contentsSuperficial fungal infections
Open this folder and view contentsSubcutaneous fungal infections
Open this folder and view contentsBacterial infections
Open this folder and view contentsViral infections
Open this folder and view contentsEczematous diseases
Open this folder and view contentsScaling diseases
Open this folder and view contentsPapulosquamous diseases
View the documentCutaneous reactions to drugs
Open this folder and view contentsPigmentary disorders
Open this folder and view contentsPremalignant lesions and malignant tumours
Open this folder and view contentsPhotodermatoses
Open this folder and view contentsBullous dermatoses
View the documentAlopecia areata
View the documentUrticaria
Open this folder and view contentsConditions common in children
View the documentAcne vulgaris
View the documentPruritus
View the documentTropical ulcers
Open this folder and view contentsAntimicrobial drugs
Open this folder and view contentsAntifugal drugs
Open this folder and view contentsAntiseptic agents
Close this folderKeratoplastic and keratolytic agents
View the documentBenzoyl peroxide
View the documentCoal tar
View the documentDithranol
View the documentSalicylic acid
View the documentTretinoin
Open this folder and view contentsScabicides and pediculicides
Open this folder and view contentsAnti-inflammatory and antipruritic drugs1
Open this folder and view contentsAntiallergics and drugs used in anaphylaxis
Open this folder and view contentsUltraviolet radiation-blocking agents (sunscreens)
Open this folder and view contentsMiscellaneous drugs
Open this folder and view contentsAnnex
View the documentSelected WHO Publications of Related Interest
View the documentBack cover
 

Tretinoin

Cream, 0.025-0.1%

General information

Tretinoin is the acid form of retinol. It is used topically in the treatment of acne. It is a keratolytic agent that reduces follicular hyperkeratosis by stimulating the turnover of epithelial cells. It is not significantly absorbed following topical application.

Clinical information

Uses

Treatment of mild to moderate acne vulgaris, especially in patients with a comedonal component.

Dosage and administration

The cream formulations cause less irritation than the gels. Treatment is usually started with the lowest-strength (0.025%) cream formulation. The strength can be increased as tolerance develops, to a maximum of 0.1%.

Adults and adolescents: a thin layer of cream should be applied to the affected areas once or twice daily, 30 minutes after washing. A therapeutic response characterized by redness and scaling occurs within 3-6 weeks. Treatment is usually continued for at least 3 months.

Contraindications

Hypersensitivity to tretinoin.

Use in pregnancy

The low blood levels that result from topically applied tretinoin have not been associated with an increase in fetal malformations. However, tretinoin should be used in women of child-bearing age only if the potential benefits outweigh the possible risks.

Precautions

Care should be taken to avoid contact with the eyes, mucous membranes and open sores. Tretinoin may produce severe irritation of the skin in patients with eczema. Exposure to ultraviolet light increases the intensity of the inflammatory reaction.

Adverse effects

Reversible local inflammatory reactions occur. Redness and scaling of the skin are necessary for a therapeutic response, but if severe erythema, blistering or crusting of the skin occurs, a lower-strength formulation should be used.

Drug interactions

Concomitant use of other topical medications for acne should be avoided. Medicated soaps and topical lotions containing high concentrations of alcohol should be avoided, since they may cause stinging of treated skin.

Storage

Cream should be stored in tightly closed containers, protected from light.

 

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