(1997; 132 pages) [French] [Spanish]
Dithranol slows epidermal cell division and inhibits excessive proliferation and keratinization of epidermal cells in patients with psoriasis.
Dithranol is not significantly absorbed following topical application.
Treatment of localized psoriasis vulgaris.
Dosage and administration
Dithranol should be used only under the direction of a physician trained in its use.
Adults and children: treatment should be started with the 0.1% ointment. After 7 days, the concentration may be increased to 0.25% and subsequently doubled, if necessary, at weekly intervals to a maximum strength of 2%.
A thin layer of ointment should be applied once daily to the affected areas for 2-4 weeks. After application, the ointment should be left in place for 10-20 minutes before rinsing thoroughly.
Dithranol should not be used on the face or on acute eruptions or excessively inflamed areas.
Care should be taken to avoid contact with normal tissue and the eyes.
If the initial treatment produces excessive soreness, or if the lesions spread, the frequency of application should be reduced. In extreme cases, treatment should be discontinued.
Patients may be more sensitive in treated sites to sun exposure.
Patients should be warned that staining of the skin and hair may occur and that clothing may be permanently stained.
Use in pregnancy
Safe use in pregnancy has not been established, but no adverse effects have been reported.
Contact with the eyes may cause severe conjunctivitis.
Skin irritation is common. Photosensitivity reactions may occur. Severe erythema may also occur on adjacent normal skin.
Ointment should be stored in tightly closed containers, protected from light.