(1997; 132 pages) [French] [Spanish]
Cream, 1% (10 mg/ml) econazole nitrate
Econazole is a synthetic imidazole active against fungi (both dermatophytes and yeasts) and Gram-positive cocci (Staphylococcus and Streptococcus spp.) which can be used as an alternative to miconazole.
Treatment of superficial fungal infections of the skin caused by both dermatophytes and yeasts and of secondary infections caused by Gram-positive cocci. Specific indications include ringworm, intertrigo, diaper dermatitis and chronic paronychia due to Candida spp., fungal infections of the outer ear and pityriasis (tinea) versicolor.
Dosage and administration
Adults and children: a thin layer of cream should be applied to all affected areas twice or 3 times daily. Treatment should be continued for 14 days after lesions have healed. In cases of tinea pedis and chronic Candida paronychia, treatment should be continued for at least 4 weeks and several months respectively.
• Known hypersensitivity to azole derivatives.
• Severe liver impairment.
Treatment should be discontinued if irritation or sensitivity occurs. Econazole should not come in contact with the eyes.
Use in pregnancy and lactation
Topically applied econazole is not systemically absorbed and can be used safely during pregnancy and lactation.
Isolated cases of sensitization have been reported, characterized by irritation and a burning sensation and necessitating discontinuation of treatment.
Econazole cream should be stored in a cool place, protected from light.