(1997; 132 pages) [French] [Spanish]
Pessary, 500 mg
Clotrimazole is a synthetic imidazole active against fungi (both dermatophytes and yeasts) and Gram-positive cocci (Staphylococcus and Streptococcus spp.) which can be used as an alternative to miconazole.
• Treatment of superficial fungal infections of the skin caused by both dermatophytes and yeasts and of secondary infections caused by Gram-positive cocci. Specific indications include ringworm, intertrigo, diaper dermatitis and chronic paronychia due to Candida spp., fungal infections of the outer ear and pityriasis (tinea) versicolor.
• Treatment of vaginal candidosis.
Dosage and administration
Superficial fungal infections of the skin and secondary infections:
Adults and children: a thin layer of cream should be applied to all affected areas twice or 3 times daily. Treatment should be continued for 14 days after lesions have healed. In tinea pedis, treatment should be continued for at least 4 weeks.
A single dose of 50 mg of cream or a pessary should be inserted high into the vagina. If relapse occurs, the dosage should be increased to 100 mg of cream daily for 12 days.
• Known hypersensitivity to azole derivatives.
• Severe liver impairment.
Treatment should be discontinued if irritation or sensitivity occurs. Clotrimazole should not come in contact with the eyes.
Use in pregnancy and lactation
Topically applied clotrimazole is not systemically absorbed and can be used safely during pregnancy and lactation.
Isolated cases of sensitization have been reported, characterized by irritation and a burning sensation and necessitating discontinuation of treatment.
Clotrimazole cream should be stored in a cool place, protected from light. Pessaries should be stored below 15°C in well-closed containers, protected from light.