(1997; 132 pages) [French] [Spanish]
Pessary, 100000 IU
Oral suspension, 100000 IU/ml
Ointment or cream, 100000 IU/g
Nystatin is an antifungal polyene antibiotic derived from Streptomyces noursei. It is effective against infections caused by a wide range of yeasts and yeast-like fungi.
Treatment of oral, vaginal and cutaneous candidosis.
Dosage and administration
All doses are suitable for adults and children.
1-2 ml of suspension four times daily.
100 000 IU as pessaries or 100 000 IU (1g) of cream inserted high into the vagina nightly for at least 2 weeks.
A thin layer of cream or ointment should be applied to all affected areas twice daily for 2 weeks.
In the above diseases, treatment should be continued for at least 48 hours after clinical cure. Higher doses and a longer period of treatment may be necessary in immunocompromised patients.
Contraindications and precautions
Treatment should be discontinued if symptoms of irritation or sensitization occur.
Use in pregnancy
Safe use in pregnancy has not been established. The need for treatment must be determined by the condition of the mother.
Mild and transient nausea, vomiting and diarrhoea may occur after oral administration. Irritation rarely occurs after topical application.
Nystatin ointment and cream should be stored in well-closed containers. Pessaries and oral suspension should be stored below 15 °C in well-closed containers, protected from light.