Use of tuberculosis interferon-gamma release assays (IGRAs) in low- and middle-income countries : policy statement
World Health Organization. (2011). Use of tuberculosis interferon-gamma release assays (IGRAs) in low- and middle-income countries : policy statement. Geneva : World Health Organization. http://www.who.int/iris/handle/10665/44759
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Noorbakhsh, S.; Mousavi, J.; Barati, M.; Shamshiri, A.R.; Shekarabi, M.; Tabatabaei, A.; Soleimani, Gh. (2011)In a cross-sectional study in a hospital in Tehran in 2006-08 the QuantiFERON[Registered]-TB interferon-gamma release assay [QTB] was compared with the tuberculin skin test [TST] in 59 young people [aged<20 years] with close contact with immunocompetent cases of proven pulmonary tuberculosis. After 1 year follow-up 10 subjects had progressed to tuberculosis disease and received treatment; TST was positive in 30% and QTB in 100%. Of the 49 non-progressive subjects, TST was positive in 10.4% and QTB in 16.3%. The agreement between TST and QTB assay ...
Interferon-gamma release assay for detection of latent tuberculosis infection in casual and close contacts of tuberculosis cases Abu Taleb, A.M.F.; El Sokkary, R.H.; El Tarhouny, S.A. (2011)The tuberculin skin test [TST] has many limitations for the diagnosis of latent tuberculosis [TB] infection. The aim of this study in Egypt was to estimate the usefulness of an interferon-gamma release assay [IFN-gamma] assay for the detection of latent TB infection in contacts of active TB cases. A total of 116 participants were enrolled and divided into 3 groups: community controls, casual [laboratory and clinic] contacts and close [household] contacts. Subjects diagnosed with latent TB infection by TST were 11.5% of controls, 71.1% of casual ...
Quantitative estimation of interferon-gamma levels among Egyptian polytransfused haematology cases Roshdy, M.N.; Harfoush, R.A.; Hamed, N.A.; Morsi, M.G. (2013)This study was designed to estimate interferon-gamma [INF-gamma] levels among polytransfused haematology cases. Cases were selected from the haematology unit of Alexandria main university hospital, Egypt. Complete blood counts, estimation of INF-gamma and hepatitis B and C virus [HBV and HCV] status were conducted on 20 unsplenectomized patients with thalassaemia major and 20 patients with acute myeloid leukaemia [AML] in the maintenance phase and 20 healthy subjects. Mean haemoglobin levels and red blood cell counts were significantly higher in ...