Summary report on the evaluation of short-term tests for carcinogens : (collaborative study on in vivo tests

Abstract

Summarizes the work of a major collaborative study concerned with the reliability of short-term tests for the in vitro assessment of mutagenicity and carcinogenicity. The study, which involved the participation of 60 key investigators, was organized in response to concern over the inability of the widely-used Salmonella, or "Ames", assay to detect carcinogenic potential in certain specific cases