Pyrrolizidine alkaloids / published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization
AbstractAlerts the medical and public health professions to the severe risks of morbidity and mortality posed by human consumption of plants, including cereals and herbal medicines, containing pyrrolizidine alkaloids. Citing well over 500 published studies, the book draws together the evidence documenting acute and often fatal organ damage arising from both accidental consumption va contaminated staple crops and the deliberate consumption, in developed and developing countries alike, of medicinal herbs containing these alkaloids. Risks to farm animals are also fully documented. The book opens with an overview of the problem, stressing the need to heighten awareness of the extent of human poisoning and the steps needed to prevent it. The most extensive sections consider effects on animals and man. Data from clinical studies and case reports are used to detail the clinical and pathological features of veno-occlusive disease in children and adults, the link between intoxication with pyrrolizidine alkaloids and the development of cirrhosis, and the relationship between dose level and toxic effects. The book concludes with 70 pages of tables listing plant sources of these alkaloids
World Health Organization, International Programme on Chemical Safety & WHO Task Group on Pyrrolizidine Alkaloids. (1988). Pyrrolizidine alkaloids / published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization. Geneva : World Health Organization. http://www.who.int/iris/handle/10665/39027
Environmental health criteria ; 80
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