Show simple item record

dc.creatorRizzo, Eda de
dc.creatorNunez Tenorio, Elisabeth Christina
dc.creatorMendes, Inacio Franca
dc.creatorLiauw Woe Fang, Francisco
dc.creatorPral, Michel Marie
dc.creatorSayoko Takata, Celia
dc.creatorMiyaki, Cosue
dc.creatorFrazatti Gallina, Neuza Maria
dc.creatorNakahata Tuchiya, Hiroko
dc.creatorKikue Akimura, Olga
dc.date.accessioned2015-12-08T03:11:09Z
dc.date.accessioned2019-02-13T23:55:10Z
dc.date.available2015-12-08T03:11:09Z
dc.date.available2019-02-13T23:55:10Z
dc.date.created2015-12-08T03:11:09Z
dc.date.issued
dc.date.issued1988
dc.identifier.urihttp://iris.paho.org/xmlui/handle/123456789/17825
dc.identifier.urihttps://apps.who.int/iris/handle/10665/305445
dc.description.abstractThe study described in this article was carried out for the purpose of evaluating the protective effects of two stabilizing solutions- sorbitol-gelatin and glutamic acid-lactose- on freeze-dried measles virus (‎Schwartz strain)‎ with a view to the production of reference preparations in working lots. The effect of storage at -20 C and -70 C on the potency of stabilized virus suspensions, whether or not freeze-dried, was evaluated over a period of 21 months; the samples were concurrently titered for potency with a standard virus obtained from a laboratory authorized by the World Health Organization. After comparing and commenting on the different phases of the study, the types of cells and stabilizing media used, how the suspensions were stored, the titering of the stabilized viruses, etc., the authors conclude that they have demostrated a more satisfactory stabilization (‎r= -0.01)‎ of freeze-dried virus suspensions stored at -20 C by sorbitol-gelatin, which is therefore regarded as an effective stabilizer for the preparation of freeze-dried reference measles virus in working lots
dc.relationBoletín de la Oficina Sanitaria Panamericana (‎OSP)‎;105(‎1)‎,jul. 1988
dc.subjectVírus do Sarampo
dc.subjectExcipientes
dc.subjectPadrões de Referência
dc.subjectVacinas Virais
dc.titleSolucoes de sorbitol-gelatina e de acido glutamico-lactose na estabilizacao de preparacoes referencia do virus do sarampo
dc.typeJournal / periodical Journal / periodical articless


Files in this item

FilesSizeFormatView
v105n1p45.pdf506.2Kbapplication/pdfView/Open

This item appears in the following Collection(‎s)‎

Show simple item record