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    • Increased dengue virus-infected endothelial cell apoptosis caused by antibodies against nonstructural protein 1. 

      Lin, Chiou-Feng; Wan, Shu-Wen; Chen, Mei-Chum; Lei, Huan-Yao; Lin, Yee-Shin (‎2007)‎
      Vascular dysfunction is a hallmark of severe dengue haemorrhagic fever (‎DHF)‎ in dengue virus (‎DENV)‎ infection. Both viral infection and immunopathogenesis are involved in the vasculopathy of DHF. We previously showed that antibodies against DENV nonstructural protein 1 (‎NS1)‎ may cross-react with endothelial cells. A further study demonstrated the pathogenic role of anti-NS1 antibodies on endothelial dysfunction by inducing cell death and inflammation. In this study, we investigated the effect of anti- NS1 antibodies on DENV-infected human endothelial ...