Frequency of the CCR5-delta 32 chemokine receptor gene mutation in the Lebanese population

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Abstract
A direct correlation between HIV infection and mutation in the chemokine receptor [CCR5] gene has been established. However, such correlation has never been investigated in Lebanon. We report the frequency of the CCR5-delta 32 mutation in a r and om sample of 209 healthy, HIV-1 seronegative Lebanese aged 19-68. Overall, 4.8% were heterozygous for the mutation. Homozygosity was absent from our sample. The frequency for the CCR5-delta 32 allele was 2.5%. Distribution of the mutation was unaffected by sex, age, religion or educational level. The frequency in the Lebanese population is consistent with that in the origin of the mutation in northern Europe. This could be attributed to a gene flow into the Middle East from northern EuropeCitation
Karam, W., Jurjus, R., Khoury, N., Khansa, H., Assad, C. et al. (2004). Frequency of the CCR5-delta 32 chemokine receptor gene mutation in the Lebanese population. EMHJ - Eastern Mediterranean Health Journal, 10 (4-5), 671-675, 2004 https://apps.who.int/iris/handle/10665/119466
Journal
EMHJ - Eastern Mediterranean Health Journal, 10 (4-5), 671-675, 2004Description
671-675ISSN
1020-3397Other Identifiers
http://applications.emro.who.int/emhj/1004_5/10_4-5_2004_671_675.pdfLanguage
EnglishCollections
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Unknown author (1994)
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World Health Organization; WHO Expert Committee on Biological Standardization (World Health Organization, 2015)