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Quinine for chloroquine-resistant falciparum malaria in pregnant Sudanese women in the first trimester

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Abstract
A prospective clinical study in eastern Sudan described the efficacy and toxicity of quinine in early pregnancy in mothers with chloroquine-resistant falciparum malaria. Twenty-six pregnant Sudanese women in their first trimester [‎mean gestational age 8.5 weeks]‎ were given quinine 10 mg/kg 3 times per day for 7 days and followed up every 2 weeks until delivery. One patient aborted [‎3.8%]‎ and 2 patients [‎7.7%]‎ experienced threatened abortion but delivered term babies. Recrudescence or re-infection was observed on day 21 in 1 patient. One baby died aged 6 months. There were no detectable congenital malformations, no auditory or visual defects or any other neurological deficits in the remaining infants at birth or 1 year later. Quinine may be safe in the first trimester of pregnancy
Citation
Adam, I., Idris, H.M. & El Bashir, M.I. (‎2004)‎. Quinine for chloroquine-resistant falciparum malaria in pregnant Sudanese women in the first trimester. EMHJ - Eastern Mediterranean Health Journal, 10 (‎4-5)‎, 560-565, 2004 https://apps.who.int/iris/handle/10665/119449
Journal
EMHJ - Eastern Mediterranean Health Journal, 10 (‎4-5)‎, 560-565, 2004
Description
560-565
ISSN
1020-3397
Other Identifiers
http://applications.emro.who.int/emhj/1004_5/10_4-5_2004_560_565.pdf
Language
English
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