Quinine for chloroquine-resistant falciparum malaria in pregnant Sudanese women in the first trimester

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Abstract
A prospective clinical study in eastern Sudan described the efficacy and toxicity of quinine in early pregnancy in mothers with chloroquine-resistant falciparum malaria. Twenty-six pregnant Sudanese women in their first trimester [mean gestational age 8.5 weeks] were given quinine 10 mg/kg 3 times per day for 7 days and followed up every 2 weeks until delivery. One patient aborted [3.8%] and 2 patients [7.7%] experienced threatened abortion but delivered term babies. Recrudescence or re-infection was observed on day 21 in 1 patient. One baby died aged 6 months. There were no detectable congenital malformations, no auditory or visual defects or any other neurological deficits in the remaining infants at birth or 1 year later. Quinine may be safe in the first trimester of pregnancyCitation
Adam, I., Idris, H.M. & El Bashir, M.I. (2004). Quinine for chloroquine-resistant falciparum malaria in pregnant Sudanese women in the first trimester. EMHJ - Eastern Mediterranean Health Journal, 10 (4-5), 560-565, 2004 https://apps.who.int/iris/handle/10665/119449