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Possible new role for angiotensin-converting enzyme inhibitors in treating glomerulonephritis

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Abstract
Serum transforming growth factor-beta [‎TGF-beta1]‎ production was estimated for 10 patients with essential hypertension, 12 patients with glomerulonephritis [‎5 hypertensive and 7 normotensive]‎ and 10 healthy controls. The glomerulonephritis group received angiotensin-converting enzyme inhibitor captopril 25-75 mg/day for 4 weeks. Blood urea, serum creatinine, 24-hour urinary protein and serum TGF-beta1 were then re-estimated. Urea and creatinine were significantly higher in the hypertension and glomerulonephritis groups than in the controls and also higher in the glomerulonephritis group than the hypertension group. TGF-beta1 was significantly higher in the glomerulonephritis groups than in the control and hypertension groups. TGF-beta1 and 24-hour urinary protein were significantly reduced in the glomerulonephritis group
Citation
Soliman, A.R., El Meligi, A.A., El Semari, M., El Shemi, M. & Mahmoud, H. (‎2003)‎. Possible new role for angiotensin-converting enzyme inhibitors in treating glomerulonephritis. EMHJ - Eastern Mediterranean Health Journal, 9 (‎3)‎, 399-406, 2003 https://apps.who.int/iris/handle/10665/119290
Journal
EMHJ - Eastern Mediterranean Health Journal, 9 (‎3)‎, 399-406, 2003
Description
399-406
ISSN
1020-3397
Other Identifiers
http://applications.emro.who.int/emhj/0903/emhj_2003_9_3_399_406.pdf
Language
English
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