Screening for congenital hypothyroidism in the Islamic Republic of Iran: strategies, obstacles and future perspectives
AbstractThe operational feasibility of a congenital hypothyroidism [CH] screening programme was assessed. Cord blood spot specimens were collected at seven Teheran hospitals and within the Damavand District health network. Cord thyroid-stimulating hormone [TSH] levels > or = 20 mU/L were recalled and levothyroxine [L-T4] therapy was started immediately after diagnosis of CH. Of 20,107 acceptable specimens, 22 neonates had CH [1:914 births]. The recall rate was 1.3%. Screening coverage was 90% of live births. Of all cord samples, only 0.2% were unacceptable either because of delay in transportation or improper specimen collection. Median ages at the time of diagnosis and starting treatment were 12 and 8 days respectively. Screening for CH is feasible and a national screening programme is a necessity
Ordookhani, A., Mirmiran, P., Hajipour, R., Hedayati, M. & Azizi, F. (2002). Screening for congenital hypothyroidism in the Islamic Republic of Iran: strategies, obstacles and future perspectives. EMHJ - Eastern Mediterranean Health Journal, 8 (4-5), 480-489, 2002 http://www.who.int/iris/handle/10665/119189
JournalEMHJ - Eastern Mediterranean Health Journal, 8 (4-5), 480-489, 2002
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Shawky, R.M.; Abdel Fattah, S.; El Din Azzam, M.E.; Rafik, M.M.; Osman, A. (2001)This study was conducted on 500 full-term neonates and 25 older patients with congenital hypothyroidism [CH], newly or previously diagnosed. Alphafetoprotein [AFP] was elevated in two neonates. In one, persistent elevation of AFP and thyroid stimulating hormone [TSH] with low thyroxine [T4] were found [congenital hypothyroidism]. In the other, AFP, TSH and T4 levels normalized [transient hypothyroidism]. The mean AFP level in new CH patients was significantly higher than in previously diagnosed patients, and was higher in CH patients than in ...