Screening for congenital hypothyroidism in the Islamic Republic of Iran: strategies, obstacles and future perspectives
AbstractThe operational feasibility of a congenital hypothyroidism [CH] screening programme was assessed. Cord blood spot specimens were collected at seven Teheran hospitals and within the Damavand District health network. Cord thyroid-stimulating hormone [TSH] levels > or = 20 mU/L were recalled and levothyroxine [L-T4] therapy was started immediately after diagnosis of CH. Of 20,107 acceptable specimens, 22 neonates had CH [1:914 births]. The recall rate was 1.3%. Screening coverage was 90% of live births. Of all cord samples, only 0.2% were unacceptable either because of delay in transportation or improper specimen collection. Median ages at the time of diagnosis and starting treatment were 12 and 8 days respectively. Screening for CH is feasible and a national screening programme is a necessity
Ordookhani, A., Mirmiran, P., Hajipour, R., Hedayati, M. & Azizi, F. (2002). Screening for congenital hypothyroidism in the Islamic Republic of Iran: strategies, obstacles and future perspectives. http://www.who.int/iris/handle/10665/119189
EMHJ - Eastern Mediterranean Health Journal, 8 (4-5), 480-489, 2002
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Hashemipour, M.; Amini, M.; Talaie, M.; Kelishadi, R.; Hovespian, S.; Iranpour, R.; Salek, M.; Haghigh, S.; Khatibi, K.H. (2007)We determined the prevalence of congenital hypothyroidism and the rate of consanguinity among parents of hypothyroid neonates among 93 381 neonates born in 17 hospitals in Isfahan from May 2002 to April 2005. Serum thyroxine [T4] and thyroid stimulating hormone [TSH] levels were measured on the 3rd-7th day of birth and neonates with abnormal levels were recalled and the levels reassessed. Those with TSH </= 10 mIU/L and T4 < 6.5 micro g/dL on the second assay were considered hypothyroid. In all, 1038 neonates were recalled and 274 were diagnosed ...
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