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Effect of leptin on LH and FSH release in ovariectomized rats

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Abstract
We compared the estradiol/progesterone-induced luteinizing hormone [‎LH]‎ and follicle-stimulating hormone [‎FSH]‎ release between normally fed and leptin-supplemented starved ovariectomized female rats and studied also the effect of hyper-leptinaemia on the steroid-induced hormonal release in normally fed ovariectomized rats. Three days' starvation completely abolished steroid-induced LH and FSH release. Significant recovery of the hormonal release was shown in the leptin-supplemented starved group. The magnitudes of LH and FSH release in the normally fed animals with a higher dose of leptin were statistically the same as those in the normally fed group without leptin. These observations indicate that physiological concentrations of circulating leptin exert a stimulatory effect on steroid-induced LH and FSH release
Citation
Shebl, M.M. (‎2002)‎. Effect of leptin on LH and FSH release in ovariectomized rats. EMHJ - Eastern Mediterranean Health Journal, 8 (‎1)‎, 105-113, 2002 https://apps.who.int/iris/handle/10665/119143
Journal
EMHJ - Eastern Mediterranean Health Journal, 8 (‎1)‎, 105-113, 2002
Description
105-113
ISSN
1020-3397
Other Identifiers
http://applications.emro.who.int/emhj/0801/EMHJ_2002_8_1_105_113.pdf
Language
English
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