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Effect of dimethyl diphenyl bicarboxylate on normal and chemically-injured liver

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Abstract
This study evaluates the effect of DDB on normal and chemically-injured liver. When given to normal rats DDB had no significant effect on liver enzymes, but in chemically-injured rats there was a significant decrease in the elevated levels of liver enzymes. DDB produced a significant increase in reduced glutathione, glutathione peroxidase and glutathione reductase, and a significant decrease in malondialdehyde and glucose-6-phosphate dehydrogenase in both normal and chemically-injured liver. The histopathology examinations showed a slight improvement with DDB administration. DDB has a beneficial effect on liver enzymes and possesses significant antioxidant properties in normal and chemically-injured liver, and may therefore be clinically useful in treating chronic viral hepatitis B in humans
Citation
El Sawy, S.A., El Shafey, A.M. & El Bahrawy, H.A. (‎2002)‎. Effect of dimethyl diphenyl bicarboxylate on normal and chemically-injured liver. EMHJ - Eastern Mediterranean Health Journal, 8 (‎1)‎, 95-104, 2002 https://apps.who.int/iris/handle/10665/119142
Journal
EMHJ - Eastern Mediterranean Health Journal, 8 (‎1)‎, 95-104, 2002
Description
95-104
ISSN
1020-3397
Other Identifiers
http://applications.emro.who.int/emhj/0801/EMHJ_2002_8_1_95_104.pdf
Language
English
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