Alphafetoprotein in screening for congenital hypothyroidism
AbstractThis study was conducted on 500 full-term neonates and 25 older patients with congenital hypothyroidism [CH], newly or previously diagnosed. Alphafetoprotein [AFP] was elevated in two neonates. In one, persistent elevation of AFP and thyroid stimulating hormone [TSH] with low thyroxine [T4] were found [congenital hypothyroidism]. In the other, AFP, TSH and T4 levels normalized [transient hypothyroidism]. The mean AFP level in new CH patients was significantly higher than in previously diagnosed patients, and was higher in CH patients than in controls. Significant relationships were found between AFP and T4, AFP and TSH, and AFP and age. AFP is a sensitive indicator of thyroid status and can be used as a screening test for hypothyroidism from the first day of life and in follow-up of CH patients
Shawky, R.M., Abdel Fattah, S., El Din Azzam, M.E., Rafik, M.M. & Osman, A. (2001). Alphafetoprotein in screening for congenital hypothyroidism. EMHJ - Eastern Mediterranean Health Journal, 7 (1-2), 171-180, 2001 http://www.who.int/iris/handle/10665/119004
JournalEMHJ - Eastern Mediterranean Health Journal, 7 (1-2), 171-180, 2001
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Screening for congenital hypothyroidism in the Islamic Republic of Iran: strategies, obstacles and future perspectives Ordookhani, A.; Mirmiran, P.; Hajipour, R.; Hedayati, M.; Azizi, F. (2002)The operational feasibility of a congenital hypothyroidism [CH] screening programme was assessed. Cord blood spot specimens were collected at seven Teheran hospitals and within the Damavand District health network. Cord thyroid-stimulating hormone [TSH] levels > or = 20 mU/L were recalled and levothyroxine [L-T4] therapy was started immediately after diagnosis of CH. Of 20,107 acceptable specimens, 22 neonates had CH [1:914 births]. The recall rate was 1.3%. Screening coverage was 90% of live births. Of all cord samples, only 0.2% were unacceptable ...