Alphafetoprotein in screening for congenital hypothyroidism

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Abstract
This study was conducted on 500 full-term neonates and 25 older patients with congenital hypothyroidism [CH], newly or previously diagnosed. Alphafetoprotein [AFP] was elevated in two neonates. In one, persistent elevation of AFP and thyroid stimulating hormone [TSH] with low thyroxine [T4] were found [congenital hypothyroidism]. In the other, AFP, TSH and T4 levels normalized [transient hypothyroidism]. The mean AFP level in new CH patients was significantly higher than in previously diagnosed patients, and was higher in CH patients than in controls. Significant relationships were found between AFP and T4, AFP and TSH, and AFP and age. AFP is a sensitive indicator of thyroid status and can be used as a screening test for hypothyroidism from the first day of life and in follow-up of CH patientsCitation
Shawky, R.M., Abdel Fattah, S., El Din Azzam, M.E., Rafik, M.M. & Osman, A. (2001). Alphafetoprotein in screening for congenital hypothyroidism. http://www.who.int/iris/handle/10665/119004
Relation
EMHJ - Eastern Mediterranean Health Journal, 7 (1-2), 171-180, 2001
Description
171-180ISSN
1020-3397Other Identifiers
http://applications.emro.who.int/emhj/0701_2/2001_7_1-2_171_180.pdfCollections
Language
EnglishMetadata
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Parental consanguinity among parents of neonates with congenital hypothyroidism in Isfahan
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Screening for congenital hypothyroidism in the Islamic Republic of Iran: strategies, obstacles and future perspectives
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