Biochemical effects of vinyl chloride monomer on the liver of occupationally exposed workers

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Abstract
We investigated the effects of vinyl chloride monomer exposure on the liver of 86 workers by measuring beta-glucuronidase, arylsulfatase A, adenosine deaminase, 5'-nucleotidase and routine liver function enzymes in the sera of the workers. In 21 of them, three or more of these parameters were raised, with a significant decrease in the level of blood glutathione and a significant increase in the enzyme activity level of glutathione S-transferase. Of these 21 workers, 14 had fatty liver infiltration, 8 of whom were also suffering from liver enlargement. Also, 4 workers had liver enlargement without fatty infiltration and 3 had enlarged spleens. The study highlights the need for vigilance in environmental monitoring and medical surveillance of workers exposed to this chemicalCitation
Saad, A.A. (2000). Biochemical effects of vinyl chloride monomer on the liver of occupationally exposed workers. EMHJ - Eastern Mediterranean Health Journal, 6 (5-6), 979-986, 2000 https://apps.who.int/iris/handle/10665/118955