Effects of single-dose praziquantel on morbidity and mortality resulting from intestinal schistosomiasis
AbstractThe long-term effect of single-dose praziquantel on morbidity and mortality from Schistosoma mansoni was investigated in surveys in 1987 and 1994 in central Sudan. Prevalence of infection dropped from 53% to 34%, and intensity of infection [400 eggs/g of faeces] from 31% to 18%. There was a reduction in hepatomegaly and hepatosplenomegaly, although splenomegaly alone was unchanged. Prevalence of periportal fibrosis decreased from 14% to 10%. Endoscopic investigation of patients with fibrosis showed a reduction in oesophageal varices from 47% to 30%. Mortality due to bleeding varices was high [community-wide, up to 11/100 infected patients with bleeding]. Thus praziquantel mass treatment can be spaced to a much longer period, reducing the expense of treatment, delivery and distribution
Kheir, M.M. (2000). Effects of single-dose praziquantel on morbidity and mortality resulting from intestinal schistosomiasis. EMHJ - Eastern Mediterranean Health Journal, 6 (5-6), 926-931, 2000 http://www.who.int/iris/handle/10665/118947
JournalEMHJ - Eastern Mediterranean Health Journal, 6 (5-6), 926-931, 2000
MetadataShow full item record
Showing items related by title and MeSH subject.
Bassiouny, H.K.; Hasab, A.A.; El Nimr, N.A.; Al Shibani, L.A.; Al Waleedi, A.A. (2014)Schistosomiasis ranks second to malaria in terms of socioeconomic and public health importance in Yemen.This study assessed the validity of a morbidity questionnaire and urine reagent strips as a rapid tool for screening schoolchildren for urinary schistosomiasis as compared with the presence of eggs in urine as the gold-standard parasitological diagnosis.The study examined urine samples and interviewed 696 children [mean age 12.5 years]attending a primary-preparatory school in south Yemen.Urinary schistosomiasis was confirmed in 126 [18.1%]chi ...
Questionnaires pour le dépistage rapide de la schistosomiase en Afrique subsaharienne / Christian Lengeler, Jürg Utzinger et Marcel Tanner Lengeler, Christian; Utzinger, Jürg; Tanner, Marcel (2002)