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Tumour necrosis factor-alpha concentration in severely asthmatic children

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Abstract
We assessed tumour necrosis factor-alpha [‎TNF-alpha]‎ concentrations in 80 asthmatic children, 26 with severe asthma in early-phase reaction, 26 with severe asthma in late-phase reaction, 28 with severe asthma controlled in between attacks with oral prednisone and 20 matched control children. TNF-alpha was measured in patients' plasma and in a supernatant of lipopolysaccharide-stimulated [‎LPS]‎ peripheral blood mononuclear [‎PBM]‎ cells. TNF-alpha concentrations in plasma and the supernatant of LPS-stimulated cells were positively correlated and the concentration also correlated positively with the time lapse between the start of the asthma attack and the time of blood sampling. TNF-alpha concentration was significantly higher in the late-phase reaction group compared to the other groups, indicating a need to counteract its release and/or effects early in asthma patients
Citation
Massoud, M.N. (‎2000)‎. Tumour necrosis factor-alpha concentration in severely asthmatic children. http://www.who.int/iris/handle/10665/118888
Relation
EMHJ - Eastern Mediterranean Health Journal, 6 (‎2-3)‎, 432-436, 2000
Description
432-436
ISSN
1020-3397
Other Identifiers
http://applications.emro.who.int/emhj/0602_3/emhj_2000_6_2_3_432_436.pdf
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  • EMRO Journal Articles (‎EMHJ)‎
Language
English
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