Genotyping human platelet alloantigens [HPA 1-5] in Saudis from Eastern Province, Saudi Arabia
AbstractIn this study we report for the first time the distribution of human platelet alloantigens [HPA] in Saudis. These antigens are implicated in the pathophysiology of alloimmune thrombocytopenia. We collected blood samples from 84 healthy male Saudi blood donors. DNA isolated by salting-out and ethanol precipitation was amplified for genes HPA 1-5 using the polymerase chain reaction/sequence specific primer method. We found high HPA-1 polymorphism similar to Caucasians. HPA-4 polymorphism in Saudis was, however, greater than in Caucasians, and more similar to that of the Japanese. These results suggest that both these two HPA systems may be clinically important in Saudis
Al Sheikh, I., Rahi, A. & Al Khalifa, M. (2000). Genotyping human platelet alloantigens [HPA 1-5] in Saudis from Eastern Province, Saudi Arabia. EMHJ - Eastern Mediterranean Health Journal, 6 (1), 168-175, 2000 http://www.who.int/iris/handle/10665/118849
JournalEMHJ - Eastern Mediterranean Health Journal, 6 (1), 168-175, 2000
MetadataShow full item record
Showing items related by title and MeSH subject.
A proposed 1st WHO reference reagent anti-human neutrophil antigen 1a (anti-HNA-1a) 09/284 / by Paul Metcalfe, Peter Rigsby, Geoff Lucas, National Institute for Biological Standards and Control, Potters Bar, UK, NHS Blood and Transplant, Filton Centre, UK World Health Organization. Biologicals Unit; WHO Expert Committee on Biological Standardization (2011 : Geneva, Switzerland) (WHO/BS/2011.2167, 2011)
Mines laid during wars and their health and human implications (draft resolution proposed by the delegations of Algeria: Democratic Yemen, Iraq, Jordan, Kuwait, Libyan Arab Jamahiriya, Mauritania, Saudi Arabia, Syrian Arab Republic, Tunisia and Yemen) World Health Assembly, 43 (A43/B/Conf.Paper No.2, 1990)
Al Gaai, E.A.; Hammami, M.M.; Al Eidan, M. (2012)We evaluated the documentation of ethical conduct [obtaining institutional review board approval and consent and following ethical guidelines] of human subject research studies published in Saudi Arabian medical journals between 1979 and 2007. Studies were classified as retrospective, prospective noninterventional, interventional or survey/interview. Of 1838 studies published in 286 journal issues of 11 Saudi Arabian medical journals, only 0.9% documented the ethical guidelines followed, with a significantly higher rate for studies published after ...