Glutathione reductase deficiency in Saudi Arabia

View/ Open
Abstract
Glutathione reductase [GR] is a ubiquitous enzyme required for the conversion of oxidized glutathione [GSSG] to reduced glutathione [GSH] concomitantly oxidizing reduced nicotinamide adenine dinucleotide phosphate [NADPH] in a reaction essential for the stability and integrity of red cells. Mutations in the GR gene and nutritional deficiency of riboflavin, a co-factor required for the normal functioning of GR, can cause GR deficiency. We conducted a study on 1691 Saudi individuals to determine the overall frequency of GR deficiency and to identify whether the deficiency results from genetic or acquired causes or both. The activity of GR was measured in freshly prepared red cell haemolysate in the presence and absence of flavin adenine dinucleotide [FAD] and the activity coefficient [AC] was determined. Samples with low GR activity [> 2.0 IU/g haemoglobin] both in the presence and absence of FAD and an AC between 0.9 and 1.2 were considered GR-deficient. Samples with AC >/= 1.3 were considered riboflavin-deficient. The overall frequency of partial GR deficiency was 24.5% and 20.3% in males and females respectively. In addition, 17.8% of males and 22.4% of females suffered from GR deficiency due to riboflavin deficiency. This could be easily corrected by dietary supplementation with riboflavin. No cases of severe GR deficiency were identifiedCitation
Warsy, A.S. & El Hazmi, M.A. (1999). Glutathione reductase deficiency in Saudi Arabia. http://www.who.int/iris/handle/10665/118820
Relation
EMHJ - Eastern Mediterranean Health Journal, 5 (6), 1208-1212, 1999
Description
1208-1212ISSN
1020-3397Other Identifiers
http://applications.emro.who.int/emhj/0506/EMHJ_1999_5_6_1208_1212.pdfCollections
Language
EnglishMetadata
Show full item recordRelated items
Showing items related by title and MeSH subject.
-
Adaptation of cytochrome-b5 reductase activity and methaemoglobinaemia in areas with a high nitrate concentration in drinking water / S. K. Gupta ... [et al.]
Gupta, S. K; Gupta, R. C; Seth, A. K; Gupta, A. B; Bassin, J. K; Gupta, A (1999) -
Patients' report of statins use and side-effects in a sample of hospitalized cardiac patients in the Islamic Republic of Iran
Mashayekhi, S.O.; Ghandforoush Sattari, M.; Baghdadchi, M.E.; Kheyri, M. (2011)We aimed to study the prevalence of the side-effects of statins among Iranians patients admitted to a cardiac-specialized hospital and had taken statins prior to hospitalization. Data was collected between September 2007 and March 2008 and 200 patients were enrolled. A questionnaire was completed using the patients' records and by interviewing the patients. The mean age of the participants was 61.5 [SD 12.3] years and 63% were males. The most commonly used statins was atrovastatin [99% of the patients]. In all, 63.5% of the participants reported ... -
WHO study on Prevention of REcurrences of Myocardial Infarction and StrokE (WHO-PREMISE) / Shanthi Mendis ... [et al.]
Mendis, Shanthi; Abegunde, Dele; Yusuf, Salim; Ebrahim, Shah; Shaper, Gerry; Ghannem, Hassen; Shengelia, Bakuti (2005)