Molecular studies on Yemeni sickle-cell-disease patients: Xmn I polymorphism
AbstractOur studies of the Saudi population have shown that in patients with mild presentation of sickle-cell disease [SCD] from Saudi Arabia's eastern region, the prevalence of polymorphic sites is high. However, the prevalence is very low in patients with severe SCD from the south-west of the country. We expanded these studies to a group of Yemeni patients with severe SCD, resident in Riyadh. We investigated a total of 60 chromosomes carrying the sickle-cell [Hb S] gene and 14 chromosomes carrying the Hb A gene. Amongst the Hb AA group, the prevalence was 42.9% and 57.1% for the presence [+] and absence [-] of Xmn I polymorphic sites. In the Hb SS individuals, the prevalence of Xmn I polymorphic sites was similar to the prevalence reported in the south-western region of Saudi Arabia
El Hazmi, M.A. & Warsy, A.S. (1999). Molecular studies on Yemeni sickle-cell-disease patients: Xmn I polymorphism. EMHJ - Eastern Mediterranean Health Journal, 5 (6), 1183-1187, 1999 http://www.who.int/iris/handle/10665/118815
JournalEMHJ - Eastern Mediterranean Health Journal, 5 (6), 1183-1187, 1999
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