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dc.contributor.authorEl Hazmi, M.A.
dc.contributor.authorWarsy, A.S.
dc.date.accessioned2014-06-17T10:42:24Z
dc.date.available2014-06-17T10:42:24Z
dc.date.issued1999EN
dc.identifier.issn1020-3397EN
dc.identifier.otherhttp://applications.emro.who.int/emhj/0506/EMHJ_1999_5_6_1159_1164.pdfEN
dc.identifier.urihttps://apps.who.int/iris/handle/10665/118811
dc.description1159-1164EN
dc.description.abstractA group of Yemeni patients with sickle-cell disease [‎SCD]‎ and normal Hb AA individuals living in Riyadh were studied to determine the incidence of the alpha-gene molecular defect. Blood samples were obtained from 26 SCD patients and 19 controls [‎the Hb AA group]‎. In the SCD patients the frequency of single alpha-gene deletion [‎-alpha/alpha alpha]‎ was 0.346, compared to 0.263 in the Hb AA group. The frequency of two gene deletion [‎-alpha/-alpha]‎ was 0.231 [‎0.0 for the Hb AA group]‎. In one Hb AA case, a triple alpha-gene arrangement [‎alpha alpha alpha/alpha alpha]‎ was found [‎frequency 0.053]‎. The results suggest that alpha-thalassaemia occurs frequently in Yemeni SCD patients. Further studies to determine the overall frequency of alpha-thalassaemia in the Republic of Yemen would be of value for patient managementEN
dc.language.isoenEN
dc.subjectAutoradiographyEN
dc.subjectCase-Control StudiesEN
dc.subjectErythrocyte CountEN
dc.subjectErythrocyte IndicesEN
dc.subjectGene DeletionEN
dc.subjectGene FrequencyEN
dc.subjectGenetic ScreeningEN
dc.subjectalpha-ThalassemiaEN
dc.subject.meshAnemia, Sickle CellEN
dc.titlePattern for alpha-thalassaemia in Yemeni sickle-cell-disease patientsEN
dc.relation.ispartofjournalEMHJ - Eastern Mediterranean Health Journal, 5 (‎6)‎, 1159-1164, 1999


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